• Preventive Nutrition and Food Science
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• v.16 no.4
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• pp.299-306
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• 2011

The present study was designed to evaluate the inhibitory effects of fermented Liriope platyphylla extract on the production of inflammation-related mediators (NO, ROS, NF-${\kappa}B$, iNOS and COX-2) and pro-inflammatory cytokines (TNF-${\alpha}$, IL-$1{\beta}$, IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Freeze-dried Liriope platyphylla was fermented by Saccharomyces cerevisiae and extracted with 70% ethanol. In lipopolysaccharide-stimulated macrophage cells, the treatment with fermented Liriope platyphylla extract decreased the generation of intracellular reactive oxygen species dose-dependently and increased antioxidant enzyme activities, including superoxide dismutase, catalase and glutathione peroxidase. Fermented Liriope platyphylla extract also inhibited NO production in lipopolysaccharide-stimulated RAW 264.7 cell. The expressions of NF-${\kappa}B$, iNOS, COX-2 and pro-inflammatory cytokines were inhibited by the treatment with fermented Liriope platyphylla extract. Thus, this study shows the fermented Liriope platyphylla extract could be effective at inhibiting the inflammation process.

• Journal of Acupuncture Research
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• v.22 no.2
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• pp.147-154
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• 2005

Objective: In this study, the effects of Liriope Platyphylla against LPS-induced inflammation was investigated. Methods: Cell viability was determined using the MTT assay. To identify expressions of COX-2 and iNOS mRNA, RT-PCR was performed. Assessment of PGE2 synthesis was performed using the PGE2 immunoassay. Measurement of NO synthesis was performed using the NO detection. Result : The MTT assay revealed that Liriope Platyphylla exerted no significant cytotoxicity in the microglial BV2 cells. RT-PCR analysis revealed that the mRNA levels of COX-2 and iNOS were significantly decreased in the LPS- and 5 mg/ml Liriope Platyphylla treated group. From the PGE2 immunoassay and NO detection, PGE2 and NO synthesis was significantly suppressed in the LPS- and 5 mg/ml Liriope Platyphylla treated group. Conclusion : In these study, Liriope Platyphylla was shown to suppress PGE2 and NO production by inhibiting LPS-stimulated enhancement of COX-2 enzyme activity and iNOS expression. It is very possible that Liriope Platyphylla can offer a valuable mode of therapy for the treatment of brain inflammatory diseases.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.39-39
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• 2023

The purpose of this study is to investigate vasodilatation effect of complex saponin separated from Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract on rabbit carotid artery. In this study, to determine vasodilatation effect of complex saponin separated from Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract on rabbit carotid artery, arterial rings with intact or damaged endothelium were used for experiment using organ bath, and were contracted by endothelin. complex saponin, major active constituents of Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with complex saponin separated from Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract may selectively accelerate cerebral blood flow through dilatation of the basilar artery. Theseis result suggest a potential role of complex saponin separated from Scrophulariae radix, Asparagus cochinchinensis and Liriope platyphylla mixture extract as source of vasodilatation agent.

• Asian Journal of Turfgrass Science
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• v.15 no.2
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• pp.77-86
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• 2001

The experiments were carried out to investigate effect of shading rare on variegata appearance and leaf growth of variegated liriope (Liriope platyphylla Wang et Tang variegata Hort.) The plant was grown under four different light intensities such as 0(natural light intensity), 25, 50 and 75% shading conditions. Leaf variegata appearance was better in the light than in the shade. Leaf showed good growth at 0, 25% shading treatment, average leaf width and area of yellow part were highest at 0% shading treatment. As increased shading rate, number of stomate per unit area decreased. Total chlorophyll of the whole leaf and green part were reduced by increasing shading rate, while yellow part showed oppositely. In the epidermis, cell size of 75% shading treatment showed larger than those of 0% shading treatment.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.47 no.3
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• pp.236-239
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• 2002

Saponin is one of major conponents in oriental medicine, which':s present in Ophiopogoneae. Saponin composition on ethyl acetate fractions from the butanolic extracts of two species, Liriope platyphylla and Ophiopogon japonicus was measured using high performance liquid chromatography (HPLC). HPLC analysis revealed that spicatoside A and B were identified in the tuber of L. platyphylla. However, spicatoside A was not identified in the tuber of O. japonicus. Related to that, it may be possible to discriminate between Liriopis and Ophiopogonis Tuber using HPLC analysis.

• Korean Journal of Medicinal Crop Science
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• v.19 no.1
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• pp.24-30
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• 2011

This text was analyzed and investigated the vegetation and floristic composition by cluster analysis and classification of phytosociological method, to evaluate the species composition, habitat environment and community structure of Liriope platyphylla and Liriope spicata group in Korea. The southeast slope gradient of the habitat of L. platyphylla and L. spicata was 6.7 to 8.4%, and the habitat altitude of L. platyphylla (41.0 m), L. spicata (114.9 m) was different. Habitat distribution of L. spicata was broader than L. platyphylla. Appearing plants of L. platyphylla and L. spicata group was 58 taxa, 99 taxa, respectively, and Coverage of tree layer was 87.5%, 92.5% respectively. In genus Liriope group, the highest appearing frequency of plant grow in the moist valley as Quercus serrata. Thus, plants of genus Liriope growth was better in moist shade. The vegetation of L. platyphylla group was classified into Quercus serrata community, Castanopsis sieboldii community, Pinus densiflora community and Pinus thunbergii community, and the Liriope spicata group was classified into Quercus serrata community, Quercus alien community, Quercus acutissima community, Prunus verecunda community, Robinia pseudoacacia community, Pinus densiflora community and Pinus thunbergii community. In genus Liriope group, Quercus serrata and Pinus densiflora communities was the closest the similarities.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.135.3-136
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• 2003

Liriope platyphylla (LP) Wang et Tang has been used for tonic, anti-tussive and expectorant in Korea. In the current study, we found that buthanol fraction of Liriope platyphylla-conditioned media of C6 and primary astrocyte induced the neurite outgrowth of PC 12 cells, which effect was reversed by addition of NGF-antibody. We demonstrated that buthanol fraction of Liriope platyphylla increased the expression and secretion of NGF through RT-PCR and ELISA. (omitted)

• Korean Journal of Pharmacognosy
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• v.39 no.2
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• pp.75-79
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• 2008

Nerve growth factor (NGF) is a protein plays a major role in the development and maintenance of central and peripheral nervous system. Recent data suggest that reduced availability of NGF may play a significant role in the pathogenesis of diabetic $polyneuropathy.^{1)}$ In our previous study, steroidal saponin from Liriope platyphylla showed neurotrophic effect by stimulation of NGF synthesis and activation of tyrosine kinase $signaling.^{2)}$ In this study, we examined the neurotrophic effect of Liriope platyphylla (LP); which was from Mylyang(MYL) and Cheongyang(CHE), and Ophiopogon japonicus (CHI) on in vitro and in vivo model for the comparison of their NGF induction. We quantitatively analyzed spicatoside A in the LP and CHI by HPLC. And we investigated the correlation between the contents of spicatoside A and NGF induction efficacy on PC 12 cells and mouse serum. These results suggest that spicatoside A may enhance NGF induction in animal model.

• KSBB Journal
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• v.29 no.5
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• pp.372-379
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• 2014

Methanol extract (1.0 wt%) of Scutellaria baicalensis George satisfied preservation standard of CTFA (The Cosmetics, Toiletry, and Fragrance Association) against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Escherichia coli which were inoculated in skin lotion. Even at a low concentration (0.01 wt%) the extract showed high superoxide dismutase-like activity. The CTFA standard could also be satisfied for the above four strains when methanol extract of Liriope platyphylla were combined with the 1.0 wt% extract of S. baicalensis George. This result suggests that extract of L. platyphylla does not hinder the preservation activity of S. baicalensis George. Moreover, skin moisture content could be maintained for 6 hours after the application of a cream containing the extract of L. platyphylla.

• Korean Journal of Pharmacognosy
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• v.34 no.1 s.132
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• pp.6-9
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• 2003

‘Maig Moon Dong(麥問冬)’ is one of the chinese crude drugs used mainly to cure a cough and sputum, etc. With regard to the botanical origin of ‘Maig Moon Dong’, it has been considered to be Liriope species of Liliaceae, but there has not been studied pharmacognostically. To clarify the botanical origin of Maig Moon Dong, we studied on the anatomical characteristics of Liriope and Ophiopogon species growing wild in Korea i.e. L. platyphylla, L. spicata, O. jaburan, O. japonicus and Maig Moon Dong from Korea. As a result, the botanical origin of Maig Moon Dong from Korea was proved as Liriope platyphylla and L. spicata.