Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Enantiomeric Compounds with Antileishimanial Activities from a Sponge, Plakortis sp

  • Lim, Chi-Won (Biotechnology Research Center, National Fisheries R & D Institute) ;
  • Kim, Yeon-Kye (Biotechnology Research Center, National Fisheries R & D Institute) ;
  • Youn, Ho-Dong (Aquaculture Environment Institute, National Fisheries R & D Institute) ;
  • Park, Hee-Yeon (Biotechnology Research Center, National Fisheries R & D Institute)
  • Published : 2006.03.30
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Abstract

As part of a program to discover bioactive natural products from marine organisms, two new enantiomers, ent-3,6-Epidioxy-4,6,8,10-tetraethyltetradeca-7,11-dienoic acid and ent-[3,5-Diethyl-5-(2-ethyl-hex-3-enyl)-5H-furan-2-ylidene]-acetic acid methyl ether, were isolated from a sponge Plakortis sp. These compounds showed strong in vitro antiproliferative effects on promastigotes of Leishmania mexicania, flagellate protozoan that causes leishmaniasis. Structures were assumed by interpretation of NMR spectroscopic data and optical rotation. Both compounds exhibited significant antileishmanial activities in vitro with $IC_{50}$ of 1.0-23.0 ${\mu}g/ml$.

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References

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