Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Cyclopia in a calf

  • Kim, Bum-Seok (Department of Medicine, Stanford University School of Medicine) ;
  • Park, Hee-Jin (Biosafety Research Institute, Chonbuk National University) ;
  • Cho, Jae-Woo (Biosafety Research Institute, Chonbuk National University) ;
  • Berzina, Dace (Biosafety Research Institute, Chonbuk National University) ;
  • Zeeshan, Muhamad (Biosafety Research Institute, Chonbuk National University) ;
  • Ejaz, Sohail (Biosafety Research Institute, Chonbuk National University) ;
  • Chekarova, Irina (Biosafety Research Institute, Chonbuk National University) ;
  • Kwon, Jung-Kee (Biosafety Research Institute, Chonbuk National University) ;
  • Lim, Chae-Woong (Biosafety Research Institute, Chonbuk National University)
  • Published : 2006.12.30
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Abstract

Cyclopia is a congenital ocular abnormality in which two orbits are fused together due to an arrest in the normal process of embryonic tissue development. Reported here is a case of cyclopia in a calf observed from the uterus of cow slaughtered in an abattoir in Korea on March 24, 2004. The calf possessed a spherical-shaped head and only one centrally placed eye. The one eyeball showed complete eyelashes on the defective eyelids. The nasal region and the anterior nares were absent along with a dorsally curved mandible extended beyond the defective maxillae.

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References

  1. Chow RL, Lang RA. 2001. Early eye development in vertebrates. Annu Rev Cell Biol 17 : 255-296 https://doi.org/10.1146/annurev.cellbio.17.1.255
  2. Liu DP, Burrowes DM, Qureshi MN. 1997. Cyclopia: Craniofacial appear ance on MR and three-dimensional CT. Am J Neuroradiol 18 : 543-546
  3. Arathi N, Mahadevan A, Santosh V, et al. 2003. Holoprosencephaly with cyclopia. Report of a pathological study. Neurol India 51 : 279-282
  4. Chakrabarti A, Pal A. 1991. Cyclopia prostomus arrhynchus in a Black Bengal goat. Indian Vet J 68 : 985-986
  5. Thippeswamy T, Prasad RV, Kakade K. 1996. A clinical case of cyclopia prostomus arrhynchus in a buffalo calf (Bubalus bubalis). Indian Vet J 73 : 674-676
  6. Dennis SM. 1975. Congenital defects of the nervous system of lambs. Aust Vet J 51(8):385-388 https://doi.org/10.1111/j.1751-0813.1975.tb15603.x
  7. Chakraborti A, Ganguli JL. 1977. Incidence of cyclopia prostomus arrynchus in an indigenous cow (Bos indicus). Indian Vet J 54 : 327-328
  8. Njoku CO, Eslevo KA, Bida SA, et al. 1978. Canine cyclopia. Vet Rec 102(3) : 60-61 https://doi.org/10.1136/vr.102.3.60
  9. Chowdhury N, Nayek K. 2002. Cyclopia. Indian Pediatr 39(10) : 973-974
  10. Incardona JP, Gaffield W, Kapur RP, et al. 1998. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125 : 3553-3562
  11. Van Kampen KR, Ellis LC. 1972. Prolonged gestation in ewes ingesting Veratrum californicum: Mor-phological changes and steroid biosynthesis in the endocrine organs of cyclopic lambs. J Endocrinol 52(3) : 549-560 https://doi.org/10.1677/joe.0.0520549