Clostridium perfringens type A associated enteritis in a Shitzu dog

  • Byun, Jae-Won (National Veterinary Research and Quarantine Service, Ministry of Agriculture and Forestry) ;
  • Yoon, Soon-Seek (National Veterinary Research and Quarantine Service, Ministry of Agriculture and Forestry) ;
  • Lim, Suk-Kyung (National Veterinary Research and Quarantine Service, Ministry of Agriculture and Forestry) ;
  • Lee, O-Soo (National Veterinary Research and Quarantine Service, Ministry of Agriculture and Forestry)
  • Published : 2006.12.30

Abstract

Acute hemorrhagic enteritis was diagnosed in a seven-month-old male Shitzu dog dying of blood stained diarrhea and vomiting. Clinical findings were anorexia, dullness and sudden death after massive bloody diarrhea. At necropsy, main lesion was the hemorrhage in small intestine, mainly duodenum and jejunum. Microscopically, Gram positive long bacilli were massively detected on the mucose epithelial cells and necrotic debris of small intestine. Coagulative necrosis of epithelial cells and thrombosis of small intestine were also identified. However, there was no lesion of crypt epithelium. Mineral infiltration in both gastric mucosa and renal tubules was detected and proliferation of fibrous tissue was also shown in corticomedullary regions. In bacterial examination, C perfringens was isolated in anaerobic culture and it was confirmed to type A by multiplex PCR. Therefore, the dog was diagnosed as C perfringens type A associated enteritis with uremia.

Keywords

References

  1. Marks SL, Kather EJ. 2005. Infectious disease of the dog and cat, 3th (Greene CE. eds.) WB Saunders Press, St. Louis, Missouri : 363-365
  2. Quinn PJ, Carter ME, Markey BK, et al. 1994. Clinical veterinary microbiology. Mosby press, London : 191-208
  3. Dennison AC, Van Metre DC, Morley PS, et al. 2005. Comparison of the odds of isolation, genotypes, and in vivo production of major toxins by Clostridium perfringens obtained from the gastrointestinal tract of dairy cows with hemorrhagic bowel syndrome or left-displaced abomasum. J Am Vet Med Assoc 227 : 132-138 https://doi.org/10.2460/javma.2005.227.132
  4. Uzal FA. 2004. Diagnosis of Clostridium perfringens intestinal infections in sheep and goats. Anaerobe 10 : 135-143 https://doi.org/10.1016/j.anaerobe.2003.08.005
  5. Songer JG, Uzal FA. 2005. Clostridial enteric infections in pigs. J Vet Diagn Invest 17 : 528-536 https://doi.org/10.1177/104063870501700602
  6. Sasaki J, Goryo M, Asahina M, et al. 1999. Hemorrhagic enteritis associated with Clostridium perfringens type A in a dog. J Vet Med Sci 61(2) : 175-177 https://doi.org/10.1292/jvms.61.175
  7. Songer JG. 1996. Clostridial enteric disease of domestic animals. Clin Microbiol Rev 9(2) : 216-234
  8. Tilton RC, Van Kruiningen HJ, Kwasnik I, et al. 1981. Toxigenic Clostridium perfringens from a parvo-virus-infected dogs. J Clin Microbiol 14(6) : 697-698
  9. Turk J, Miller M, Pace L, et al. 1992. Enteric Clostridium perfringens infection associated with parvovirial enteritis in dogs: 74 case(1987-1990). JAVMA 200 : 991-994
  10. Park HM, Oh TH, Kim HU, et al. 1999. Occurrence of suspected infection of Camphylobacter spp and Clostridium spp in dogs with chronic diarrhea. Korean J Vet Res 39(4) : 819-824
  11. Tribe GW, Kerr MG. 2001. Toxicosis in dogs exposed to Clostridium perfringens type A. Vet Rec 149 : 310-311
  12. Yoo HS, Lee SU, Park KY, et al. 1997. Molecular typing and epidemio-logical survey of prevalence of Clostridium perfringens types by multiplex PCR. J Clin Microbiol 35(1) : 228-232
  13. Barker IK, Van Dreumel AA, Palmer N. 1993. Pathology of domestic animals. 4eds.(Jubb KVF, Kennedy PC, Palmer N eds.), Academic Press, San Diego : 237-247, 454-459
  14. Pritchet SJ. 1991. Enterotoxemia in dogs. Vet Rec 129 : 391
  15. Majeed SK. 1985. Mineralisation in kidney and stomach of Beagle dogs. Vet Q 79(2) : 162-164