Toxicological Research

  • 제22권4호
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  • Pages.453-458
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  • 2006
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

마우스에 대한 Surfactin C의 급성경구독성시험

Acute Oral Toxicity of Surfactin C in Mice

  • Park, Byung-Kwon (College of Veterinary Medicine, Chungnam National University) ;
  • Lim, Jong-Hwan (B&C Biopharm) ;
  • Hwang, Youn-Hwan (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Myung-Seok (College of Veterinary Medicine, Chungnam National University) ;
  • Song, In-Bae (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Hong-Gee (College of Veterinary Medicine, Chungnam National University) ;
  • Han, Sung-Jin (College of Veterinary Medicine, Chungnam National University) ;
  • Hwang, Mi-Hyun (College of Veternary Medicine, Kyoungbuk National University) ;
  • Kim, Jong-Woo (B&C Biopharm) ;
  • Rhee, Man-Hee (College of Veternary Medicine, Kyoungbuk National University) ;
  • Park, Seong-Chung (College of Veternary Medicine, Kyoungbuk National University) ;
  • Yun, Hyo-In (College of Veterinary Medicine, Chungnam National University)
  • 발행 : 2006.12.30
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초록

This study was carried out to investigate the acute toxicity of surfactin C in mice. Surfactin C was administered orally at does of 0, 381, 610, 977, 1562 and 2500 mg/kg. Number of deaths, clinical signs, body weights, feed and water consumptions, and biochemical examinations were investigated for 14 days after single oral administration of surfactin C. $LD_{50}$ value was over 2500mg/kg in mice. In addition, no differences were found between control and treated groups in clinical signs, body weight gains, hematology, serum chemistry, feed and water consumptions. The results indicate that surfactin C did not show any toxic effects at 2500 mg/kg in mice.

키워드

참고문헌

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