Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-proliferation Effects of Isorhamnetin Isolated from Persicaria thunbergii on Cancer Cell Lines

  • Lee, Su-Kyung (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kwon, Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University) ;
  • Kim, Sung-Hoon (Lab. of Angiogenesis and Chemoprevention, Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Jae-Hyeok (Department of Oriental Pharmaceutical development, Nambu University) ;
  • Park, Hee-Wook (College of Pharmacy, Woosuk University) ;
  • Kim, Ju-Sin (College of Pharmacy, Woosuk University) ;
  • Moon, Mi-Kyeong (College of Pharmacy, Woosuk University) ;
  • Kim, Dae-Keun (College of Pharmacy, Woosuk University)
  • Published : 2006.12.30
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Abstract

Isorhamnetin from the aerial parts of Persicaria thunbergii has been reported to have anti-tumor activity mediated by the inhibition of farnesyl protein transferase. In this study, we investigated the anti-proliferation effects of isorhamnetin on NIH3T3, K-RAS, H-RAS and SW620 cells, and it showed anti-proliferative effects in a dose-dependent manner with $IC_{50}$ value 4.1, 7.9, 20.2, and $22.4{\mu}g/ml$, repectively.

Keywords

References

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