대한의생명과학회지 (Biomedical Science Letters)
- 제12권4호
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- Pages.435-438
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- 2006
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Induction of ER-stress by Heat Shock in the Thyrocytes
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- 양영모 (을지의과대학병원 응급의학과)
- Kwon, Ki-Sang (Department of Anatomy, College of Medicine, Chungnam National University) ;
- Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University) ;
- Yang, Young-Mo (Department of Emergency Medicine, School Medicine, Eulji University)
- 발행 : 2006.12.31
초록
In eukaryotes, ER stress induces UPR (unfolded protein response) via IRE1 activation which sends a molecular signal for XBP1 mRNA splicing in the cytosol. During this mRNA splicing, 23 nt removed in which contains PstI site and then resulting XBP1 product is not digested with PstI restriction enzyme. In this study, using this XBP1 mRNA splicing mechanism, the effect of heat shock on thyrocytes is studied, because heat shock response in the thyrocytes needs more study to understand thyroid physiology under alternative environments. ER inducible drugs (tunicamycin, DTT,