Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Sedative Effects of Combined Administration of 4-Hydroxy-3-methoxybenzaldehyde, a Component of Gastrodia elata, and 2,3-Dihydroxybenzaldehyde in Rats

천마성분인 4-hydroxy-3-methoxybenzaldehyde와 2,3-dihydroxy-benzaldehyde의 병용투여에 의한 진정효과

  • Lee, Dong-Ung (Department of Biotechnology Dongguk University) ;
  • Choi, Hyung-Chul (Department of Pharmacology College of Medicine, Yeungnam University) ;
  • Lee, Kwang-Youn (Department of Pharmacology College of Medicine, Yeungnam University) ;
  • Lee, Soo-Kwan (Department of Pediatrics, College of Medicine, Yeungnam University) ;
  • Kim, Jung-Ae (College of Pharmacy, Yeungnam University) ;
  • Yong, Chul-Soon (College of Pharmacy, Yeungnam University) ;
  • Kim, Jin-Sook (College of Pharmacy, Yeungnam University) ;
  • Huh, Geun (College of Pharmacy, Yeungnam University) ;
  • Shin, Son-Moon (Department of Pediatrics, School of Medicine, Sungkyunkwan University) ;
  • Koo, Byung-Soo (Department of Oriental Neuropsychiatry, Dongguk University) ;
  • Ha, Jeoung-Hee (Department of Pharmacology, School of Medicine, Kyungpook National University)
  • 이동웅 (동국대학교 과학기술대학 생명공학과) ;
  • 최형철 (영남대학교 의과대학 약리학교실) ;
  • 이광윤 (영남대학교 의과대학 약리학교실) ;
  • 이수관 (영남대학교 의과대학 소아과학교실) ;
  • 김정애 (영남대학교 약학대학) ;
  • 용철순 (영남대학교 약학대학) ;
  • 김진숙 (영남대학교 약학대학) ;
  • 허근 (영남대학교 약학대학) ;
  • 신손문 (성균관대학교 의과대학 소아과학교실) ;
  • 구병수 (동국대학교 한의과대학 신경정신과) ;
  • 하정희 (경북대학교 의과대학 약리학교실)
  • Published : 2006.12.01
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Abstract

The present study was performed to investigate the sedative effects of the combined administration of phenolic compounds. 4-hydroxy-3-methoxybenzaldehyde, a component of Gastrodia elnta, showing positive GABAergic neuromodulation was administered intraperitoneally together with an identical dose of 2,3-dihydroxybenzaldehyde, a potent antioxidant, to the rats and then evaluated for its effects on the convulsion, the hypnosis, the inxiety and the muscle relaxation. Combined administration of both compounds significantly reduced the pentyleneterazole-induced lethality. In addition, this mixture significantly enhanced the pentobarbital-induced sleeping time. Contrary to the anticonvulsive and sedative effects, the combined administration did not exhibit anxiolytic or muscle relaxant activities. These results indicated that the combined treatment of 2,3-dihydroxybenzaldehtyde and 4-hydroxy-3-methoxybenzaldehyde with different effects leads to the anticonvulsion and/or sedation

페놀성 화합물들의 병용투여가 rat의 진정효과에 미치는 영향을 조사하였다. 천마성분으로서 positive GABAergic neuromodulation을 보이는 4-hydroxy-3-methoxybenzaldehyde와 강력한 항산화물질인 2,3-dihydroxlrbenzaldehyde를 동량 투여한 결과, pentyleneterazole에 의해 유발된 사망률이 유의하게 감소되었으며 pentobarbital에 의해 유도된 수면시간은 유의하게 연장되었으나 항불안효과와 근육이완효과는 나타나지 않았다. 이러한 결과로 보아 항경련효과를 가진 화합물과 항산화 효과를 가진 화합물을 병용투여 함으로서 경련이나 불면 등의 신경증상을 효과적으로 억제할 수 있을 것으로 사료된다.

Keywords

References

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