Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Commonly used herbal medicines in the treatment for female reproductive dysfunction

  • Imai, Atsushi (Department of Obstetrics and Gynecology, Gifu University School of Medicine)
  • Published : 2006.03.30
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Abstract

Herbal medicines are widely used for centuries to treat illness and improve health in Asia and the use of these remedies has become a worldwide form of alternative therapy. However, there is very limited evidence from randomized controlled trials to support the efficacy of the vast majority of herbal products. Of the commonly used herbal medicines, systemic clinical experiences and promising experiments in animals have found potential evidence of efficacy for six herbal medicines (Unkei-to, Hachimijio-gan, Keishi-bukuryo-gan, Toki-shakuyaku-san, Shakuyaku-kanzo-to, Sairei-to) in the treatment for female reproductive dysfunction. Because herbs may contain potent bioactive substances, the physician should have an opportunity to outline more stringent regulation, similar to over-the counter drug.

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References

  1. Akase T, Akase T, Onodera S, Jobo T, Matsushita R, Kaneko M, Tashiro S. (2003) A comparative study of the usefulness of toki-shakuyaku-san and an oral iron preparation in the treatment of hypochromic anemia in cases of uterine myoma. Yakugaku Zasshi 123, 817-824. https://doi.org/10.1248/yakushi.123.817
  2. Akase T, Onodera S, Matsushita R, Akase T, Tashiro S. (2004) A comparative study of laboratory parameters and symptoms effected by Toki-shakuyaku-san and an iron preparation in rats with iron-deficiency anemia. Biol. Pharm. Bull. 27, 871-878. https://doi.org/10.1248/bpb.27.871
  3. Amato P, Marcus D. (2003) Review of alternative therapies for treatment of menopausal symptoms. Climacteric 6, 278-284. https://doi.org/10.1080/cmt.6.4.278.284
  4. Aung H, Dey L, Rand V, Yuan C. (2004) Alternative therapies for male and female sexual dysfunction. Am. J. Chin. Med. 32, 161-173. https://doi.org/10.1142/S0192415X04001837
  5. Bent S, Ko R. (2004) Commonly used herbal medicines in the United States. Am. J. Med. 116, 478-485. https://doi.org/10.1016/j.amjmed.2003.10.036
  6. Blanc P, Trupin L, Earnest G, Katz P, Yelin E, Eisner M. (2001) Alternative therapies among adults with a reported diagnosis of asthma or rhinosinusitis : data from a population-based survey. Chest 120, 1461-1467. https://doi.org/10.1378/chest.120.5.1461
  7. Brechin S, Owen P. (2003) Management of premenstrual dysphoric disorder. Hosp. Med. 64, 348-351. https://doi.org/10.12968/hosp.2003.64.6.348
  8. Burstein H, Gelber S, Guadagnoli E, Weeks J. (1999) Use of alternative medicine by women with early-stage breast cancer. N. Engl. J. Med. 340, 1733-1739. https://doi.org/10.1056/NEJM199906033402206
  9. Chen J, Shiraki M. (2003) Menopausal hot flash and calciotonin gene-related peptide; effect of Keishibukuryo-gan, a kampo medicine, related to plasma calciotonin gene-related peptide level. Maturitas 45, 199-204. https://doi.org/10.1016/S0378-5122(03)00128-2
  10. Chung M. (2004) Vitamins, supplements, herbal medicines, and arrhythmias. Cardiol. Reν. 12, 73-84. https://doi.org/10.1097/01.crd.0000091839.22076.f4
  11. Corns C. (2003) Herbal remedies and clinical biochemistry. Ann. Clin. Biochem. 40, 489-507. https://doi.org/10.1258/000456303322326407
  12. Dattner A. (2003) From medical herbalism to phytotherapy in dermatology: back to the future. Dermatol. Ther. 16, 106-113. https://doi.org/10.1046/j.1529-8019.2003.01618.x
  13. Dattner A. (2004) Herbal and complementary medicine in dermatology. Dermatol. Clin. 22, 325-332. https://doi.org/10.1016/j.clindermatol.2004.01.007
  14. De Smet P. (2002) Herbal remedies. N. Engl. J. Med. 347, 2046-2056. https://doi.org/10.1056/NEJMra020398
  15. De Smet P. (2004) Health risks of herbal remedies: an update. Clin. Pharmacol. Ther. 76, 1-17. https://doi.org/10.1016/j.clpt.2004.03.005
  16. Ehling D. (2001) Oriental medicine: an introduction. Altern. Ther. Health Med. 7, 71-82.
  17. Ergil K, Kramer E, Ng A. (2002) Chinese herbal medicines. West J. Med. 176, 275-279.
  18. Ernst E. (2004a) Are herbal medicines effective? Int. J. Clin. Pharmacol. Ther. 42, 157-159. https://doi.org/10.5414/CPP42157
  19. Ernst E. (2004b) Prescribing herbal medications appropriately. J. Fam. Pract. 53, 985-988.
  20. Ernst E, Pittler M. (2002) Herbal medicine. Med. Clin. North Am. 86, 149-161. https://doi.org/10.1016/S0025-7125(03)00077-4
  21. Espey L. (1988) Ovulation as an inflammatory reaction: a hypothesis. Biol. Reprod. 22, 73-106. https://doi.org/10.1095/biolreprod22.1.73
  22. Fujii O, Kanai T, Kouzuma S, Baba K, Miki A, Hyodo H, Yamashita T, Unno N, Taketani Y. (2001) Herbal medicines, Sairei-to and Tokishakuyaku-san, differently modulate the release of cytokines from decidual versus peripheral blood mononuclear cells. Am. J. Reprod. Immunol. 46, 369-372. https://doi.org/10.1034/j.1600-0897.2001.d01-26.x
  23. Fujii T. (2002) Herbal factors in the treatment of autoimmunity-related habitual abortion. Vitam. Horm. 65, 333-344. https://doi.org/10.1016/S0083-6729(02)65070-8
  24. Fujii T, Kanai T, Kozuma S, Hamai Y, Hyodo H, Yamashita T, Miki A, Unno N, Taketani Y. (2000) Theoretical basis for herbal medicines, Tokishakuyaku-san and Sairei-to, in the treatment of autoimmunity-related recurrent abortion by correcting T helper-1/T helper-2 balance. Am. J. Reprod. Immunol. 44, 342-346. https://doi.org/10.1111/j.8755-8920.2000.440604.x
  25. Fujitsuka N, Goto K, Takeda S, Aburada M. (2004) The diuretic effect of Sairei-to is mediated by nitric oxide production in pentobarbital-anesthetized rats. J. Pharmacol. Sci. 94, 185-191. https://doi.org/10.1254/jphs.94.185
  26. Gallo M, Einarson A, Koren G. (2003) Herbal medicine use in pregnancy: a new frontier in clinical teratology. Birth Defects Res. B. Dev. Reprod. Toxicol. 68, 499-500. https://doi.org/10.1002/bdrb.10051
  27. He J, Akao T, Nishino T, Tani T. (2001) The influence of commonly prescribed synthetic drugs for peptic ulcer on the pharmacokinetic fate of glycyrrhizin from Shaoyao-Gancao-tang. Biol. Pharm. Bull. 24, 1395-1399. https://doi.org/10.1248/bpb.24.1395
  28. Heber D. (2003) Herbal preparations for obesity: are they useful? Prim. Care 30, 441-463. https://doi.org/10.1016/S0095-4543(03)00015-0
  29. Hidaka S, Okamoto Y, Nakajima K, Suekawa M, Liu S. (1997) Preventive effects of traditional Chinese (Kampo) medicines on experimental osteoporosis induced by ovariectomy in rats. Calcif. Tissue Int. 61, 239-246. https://doi.org/10.1007/s002239900329
  30. Imai A, Horibe S, Fuseya S, Iida K, Takagi H, Tamaya T. (1995) Possible evidence that the herbal medicine shakuyaku-kanzo-to decreases prostaglandin levels through suppressing arachidonate turnover in endometrium. J. Med. 26, 163-174.
  31. Irahara M, Yasui T, Tezuka M, Ushigoe K, Yamano S, Kamada M, Aono T. (2000) Evidence that Tokishakuyaku-san and its ingredients enhance the secretion of a cytokine-induced neutrophil chemoattractant (CINC/gro) in the ovulatory process. Methods Find. Exp. Clin. Pharmacol. 22, 725-730. https://doi.org/10.1358/mf.2000.22.10.802288
  32. Ishikawa H, Manabe F, Zhongtao H, Yoshii S, Koiso K. (1992) The hormonal response to HCG stimulation in patients with male infertility before and after treatment with hochuekkito. Am. J. Chin. Med. 20, 157-165. https://doi.org/10.1142/S0192415X92000163
  33. Ito T, Seo N, Yagi H, Ohtani T, Tokura Y, Takigawa M, Furukawa F. (2002) Unique therapeutic effects of the Japanese-Chinese herbal medicine, Sairei-to, on Th1/Th2 cytokines balance of the autoimmunity of MRL/lpr mice. J. Dermatol. Sci. 28, 198-210. https://doi.org/10.1016/S0923-1811(01)00161-X
  34. Joyal S. (2004) A perspective on the current strategies for the treatment of obesity. Curr. Drug Targets CNS Neurol. Disord. 3, 541-356.
  35. Jurgens T. (2003) Potential toxicities of herbal therapies in the developing fetus. Birth Defects Res. B. Dev. Reprod. Toxicol. 68, 496-498. https://doi.org/10.1002/bdrb.10050
  36. Kroon V, Boyd L. (2001) Menopause: choices for women. Aust. Nurs. J. 8, 1-4.
  37. Lu A, Jia H, Xiao C, Lu Q. (2004) Theory of traditional Chinese medicine and therapeutic method of diseases. World J. Gastroenterol. 10, 1854-1856. https://doi.org/10.3748/wjg.v10.i13.1854
  38. Mori T, Sakamoto S, Singtripop T, Park M, Kato T, Kawashima S, Nagasawa H. (1993) Suppression of spontaneous development of uterine adenomyosis by a Chinese herbal medicine, keishi-bukuryo-gan, in mice. Planta Med. 59, 308-311. https://doi.org/10.1055/s-2006-959687
  39. Nelson P, Montgomery B. (2003) Unconventional therapy for prostate cancer: good, bad or questionable? Nat. Rev. Cancer 3, 845-858. https://doi.org/10.1038/nrc1210
  40. Noguchi M, Ikarashi Y, Yuzurihara M, Kase Y, Chen J, Takeda S, Aburada M, Ishige A. (2003a) Effects of the Japanese herbal medicine Keishi-bukuryo-gan and 17beta-estradiol on calcitonin gene-related peptide-induced elevation of skin temperature in ovariectomized rats. J. Endocrinol. 176, 359-366. https://doi.org/10.1677/joe.0.1760359
  41. Noguchi M, Ikarashi Y, Yuzurihara M, Kase Y, Takeda S, Aburada M. (2003b) Effects of 17 beta-estradiol and the Japanese herbal medicine Keishibukuryo-gan on the release and synthesis of calcitonin gene-related peptide in ovariectomized rats. J. Pharmacol. Sci. 93, 80-86. https://doi.org/10.1254/jphs.93.80
  42. Ota H, Igarashi S, Tanaka T. (1999) Improved fertility through superoxide removal by Toki-shakuyakusan in mice-a preliminary study. Reprod. Fertil. Dev. 11, 451-455. https://doi.org/10.1071/RD00001
  43. Ota H, Tanaka H, Kodama H, Fukuda J, Karube H, Tanaka T. (1996) Effect of kampo prescriptions on the secretion of interleukin-6 in human granulose cells. Jpn. J. Fertil. Steril. 41, 76-81.
  44. Otani S, Usuki S, Iwasaki H, Inoue S, Yamashita K. (1991) Successful treatment of a hyperprolactinemic infertile woman with a pituitary microadenoma using hachimijiogan. Am. J. Chin. Med. 9, 145-154.
  45. Pal S, Shukla Y. (2003) Herbal medicine: current status and the future. Asian Pac. J. Cancer Prev. 4, 281-288.
  46. Rao J, Mihaliak K, Kroenke K, Bradley J, Tierney W, Weinberger M. (1999) Use of complementary therapies for arthritis among patients of rheumatologists. Ann. Intern. Med. 131, 409-416.
  47. Rostom AY. (2001) The management of menopausal sequelae in patients with breast cancer. Clin. Oncol. 13, 174-180.
  48. Russell L, Hicks G, Low A, Shepherd J, Brown C. (2002) Phytoestrogens: a viable option? Am. J. Med. Sci. 324, 185-188. https://doi.org/10.1097/00000441-200210000-00004
  49. Sakai A, Kondo Z, Kamei K, Izumi S, Sumi K. (1999) Induction of ovulation by Sairei-to for polycystic ovary syndrome patients. Endocr. J. 46, 217-220. https://doi.org/10.1507/endocrj.46.217
  50. Sakamoto S, Mitamura T, Iwasawa M, Kitsunai H, Shindou K, Yagishita Y, Zhou Y, Sassa S. (1998) Conservative management for perimenopausal women with uterine leiomyomas using Chinese herbal medicines and synthetic analogs of gonadotropin-releasing hormone. In Vivo 12, 333-337.
  51. Sakamoto S, Yoshino H, Shirahata Y, Shimodairo K, Okamoto R. (1992) Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas. Am. J. Chin. Med. 20, 313-317. https://doi.org/10.1142/S0192415X92000333
  52. Smith M, Boon H. (1999) Counseling cancer patients about herbal medicine. Patient Educ. Couns. 38, 109-120. https://doi.org/10.1016/S0738-3991(99)00058-0
  53. Strader D, Bacon B, Lindsay K, La Brecque D, Morgan T, Wright E, Allen J, Khokar M, Hoofnagle J, Seeff L. (2002) Use of complementary and alternative medicine in patients with liver disease. Am. J. Gastroenterol. 97, 2391-2397. https://doi.org/10.1111/j.1572-0241.2002.05993.x
  54. Sun F, Yu J. (2000) The effects of a special herbal tea on obesity and anovulation in androgen-sterilized rats. Proc. Soc. Exp. Biol. Med. 223, 295-301. https://doi.org/10.1046/j.1525-1373.2000.22342.x
  55. Sun W, Imai A, Tagami K, Sugiyama M, Furui T, Tamaya T. (2004) In vitro stimulation of granulose cells by unkei-to results from a combination of different active ingredients. Am. J. Chin. Med. 32, 569-578. https://doi.org/10.1142/S0192415X0400220X
  56. Takahashi K, Kitao M. (1994) Effect of TJ-68 (shakuyaku-kanzo-to) on polycystic ovarian disease. Int. J. Fertil. Menopausal. Stud. 39, 69-76.
  57. Takakuwa K, Arakawa M, Honda K, Imai T, Tamura M, Kurabayashi T, Tanaka K. (1997) Immunosuppressive therapy for recurrent aborters with positive antiphospholipid antibodies and alteration of 6ketoPGF1 alpha/TXB2 ratio. J. Perinat. Med. 25, 509-511. https://doi.org/10.1515/jpme.1997.25.6.509
  58. Takakuwa K, Yasuda M, Hataya I, Sekizuka N, Tamura M, Arakawa M, Higashino M, Hasegawa I, Tanaka K. (1996) Treatment for patients with recurrent abortion with positive antiphospholipid antibodies using a traditional Chinese herbal medicine. J. Perinat. Med. 24, 489-494. https://doi.org/10.1515/jpme.1996.24.5.489
  59. Takei H, Nakai Y, Hattori N, Yamamoto M, Kurauchi K, Sasaki H, Aburada M. (2004) The herbal medicine Toki-shakuyaku-san improves the hypertension and intrauterine growth retardation in preeclampsia rats induced by Nomega-nitro-L-arginine methyl ester. Phytomedicine 11, 43-50. https://doi.org/10.1078/0944-7113-00332
  60. Taketani Y, Kugu K, Hayashi N, Mizuno M. (1988) Action of Unkei-to on cultured rat pituitary cells. In: Recent Advances in the Pharmacology of Kampo (Japanese Herbal) Medicine, edited by Hosoya E, Yamamura Y, pp. 184-190, Excepta Medica, Tokyo.
  61. Tanaka T. (2001) Effects of herbal medicines on menopausal symptoms induced by gonadotropin-releasing hormone agonist therapy. Clin. Exp. Obstet. Gynecol. 28, 20-23.
  62. Tanaka T. (2003) A novel anti-dysmenorrhea therapy with cyclic administration of two Japanese herbal medicines. Clin. Exp. Obstet. Gynecol. 30, 95-98. https://doi.org/10.1016/S0889-8545(02)00055-4
  63. Tanaka T, Mizuno K, Umesaki N, Ogita S. (1998) A preliminary immunopharmacological study of an antiendometriotic herbal medicine, Keishibukuryo-gan. Osaka City Med. J. 44, 117-124.
  64. Tanaka T, Umesaki N, Mizuno K, Fujino Y, Ogita S. (2000) Anti-endometrial IgM autoantibodies in endometriotic patients: a preliminary study. Clin. Exp. Obstet. Gynecol. 27, 133-137.
  65. Terranova P, Rice V. (1997) Cytokine involvement in ovarian processes. Am. J. Reprod. Immunol. 37, 50-63. https://doi.org/10.1111/j.1600-0897.1997.tb00192.x
  66. Thompson Coon J, Ernst E. (2003) Herbs for serum cholesterol reduction: a systematic view. J. Fam. Pract. 52, 468-478.
  67. Ushigoe K, Irahara M, Fukumochi M, Kamada M, Aono T. (2000) Production and regulation of cytokine-induced neutrophil chemoattractant in rat ovulation. Biol. Reprod. 63, 121-126. https://doi.org/10.1095/biolreprod63.1.121
  68. Ushiroyama T. (2003) Endocrinological actions of Unkei-to, a herbal medicine, and its clinical usefulness in anovulatory and/or infertile women. Reprod. Med. Biol. 2, 45-61. https://doi.org/10.1046/j.1445-5781.2003.00019.x
  69. Ushiroyama T, Ikeda A, Sakai M, Hosotani T, Suzuki Y, Tsubokura S, Ueki M. (2001) Effects of Unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion. J. Reprod. Med. 46, 451-456.
  70. Ushiroyama T, Tsubokura S, Ikeda A, Ueki M. (1995) The effect of Unkei-to on pituitary gonadotropin secretion and ovulation in anovulatory cycles of young women. Am. J. Chin. Med. 23, 223-230. https://doi.org/10.1142/S0192415X95000274
  71. Usuki S, Usuki Y. (1989) Hachimijiogan treatment is effective in the management of infertile women with hyperprolactinemia or bromocriptine-resistant hyperprolactinemia. Am. J. Chin. Med. 17, 225-241. https://doi.org/10.1142/S0192415X89000322
  72. Usuki S. (1991) Effects of hachimijiogan, tokishakuyakusan, keishibukuryogan, ninjinto and unkeito on estrogen and progesterone secretion in preovulatory follicles incubated in vitro. Am. J. Chin. Med. 19, 65-71. https://doi.org/10.1142/S0192415X91000107
  73. Usuki S, Ichikawa Y. (1991) Effects of hachimijiogan on dopamine, serotonin and vasoactive intestinal peptide in plasma and hypothalamus in sulpiride-induced hyperprolactinemic rats. Am. J. Chin. Med. 19, 217-222. https://doi.org/10.1142/S0192415X91000296
  74. Usuki S, Kotani E, Kawakura Y, Sano M, Katsura Y, Kubo T. (1995) Tokishakuyakusan effect on DNA polymerase alpha activity in relationship to DNA synthesis before and/or after the LH/FSH surge in rats. Am. J. Chin. Med. 23, 231-242. https://doi.org/10.1142/S0192415X95000286
  75. Usuki S, Higa T, Soreya K. (2002) The improvement of luteal insufficiency in fecund women by tokishakuyakusan treatment. Am. J. Chin. Med. 30, 327-338. https://doi.org/10.1142/S0192415X02000247
  76. Usuki S, Kotani E. (2002) Tokishakuyakusan directly attenuates PACAP's luteolytic action on luteal function in the rat ovary. Am. J. Chin. Med. 30. 521-531. https://doi.org/10.1142/S0192415X02000545
  77. Veal L. (1998) Complementary therapy and infertility: an Icelandic perspective. Complement. Ther. Nurs. Midwifery 4, 3-6. https://doi.org/10.1016/S1353-6117(98)80003-6
  78. Weier K, Beal M. (2004) Complementary therapies as adjuncts in the treatment of postpartum depression. J. Midwifery Wom. Heal. 49. 96-104. https://doi.org/10.1016/j.jmwh.2003.12.013
  79. Westfall R. (2001) Herbal medicine in pregnancy and childbirth. Adv. Ther. 18, 47-55. https://doi.org/10.1007/BF02850250
  80. Yamada K, Kanba S, Murata T, Fukuzawa M, Terashi B, Yagi G, Asai M. (1996) Effectiveness of shakuyaku-kanzo-to in neuroleptic-induced hyperprolactinemia: a preliminary report. Psychiatry Clin. Neurosci. 50, 341-342. https://doi.org/10.1111/j.1440-1819.1996.tb00578.x
  81. Yamada K, Kanba S, Yagi G, Asai M. (1997) Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. J. Clin. Psychopharmacol. 17, 234-235. https://doi.org/10.1097/00004714-199706000-00025
  82. Yamada K, Kanba S, Yagi G, Asai M. (1999) Herbal medicine (Shakuyaku-kanzo-to) in the treatment of risperidone-induced amenorrhea. J. Clin. Psychopharmacol. 19, 380-381. https://doi.org/10.1097/00004714-199908000-00018
  83. Yamamoto K, Hoshiai H, Noda K. (2001) Effects of shakuyaku-kanzo-to on muscle pain from combination chemotherapy with paclitaxel and carboplatin. Cynecol. Oncol. 81, 333-334. https://doi.org/10.1006/gyno.2001.6168
  84. Yasui T, Matsuzaki T, Ogata R, Kiyokawa M, Ushigoe K, Uemura H, Kuwahara A, Ikawa H, Maegawa M, Furumoto H, Aono T, Irahara M. (2003) The herbal medicine Unkei-to stimulates the secretion of a cytokine-induced neutrophil chemoattractant, CINC/gro, in the rat ovarian cell culture. Am. J. Reprod. Immunol. 49, 14-20. https://doi.org/10.1034/j.1600-0897.2003.01145.x
  85. Yasui T, Matsuzaki T, Ushigoe K, Kuwahara A, Maegawa M, Furumoto H, Aono T, Irahara M. (2003) Stimulatory effect of the herbal medicine Keishi-bukuryo-gan on a cytokine-induced neutrophil chemoattractant, in rat ovarian cell culture. Am. J. Reprod. Immunol. 50, 90-97. https://doi.org/10.1034/j.1600-0897.2003.00055.x
  86. Zhou S, Koh H, Gao Y, Gong Z, Lee E. (2004) Herbal bioactivation: the good, the bad and the ugly. Life Sci. 74, 935-968. https://doi.org/10.1016/j.lfs.2003.09.035