Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-inflammatory and Immunomodulatory Effects of the Botanical Product $AMP-365^{TM}$

천연물제제 마루플랜트$-AMP-365^{TM}$의 항염증 및 면역활성에 미치는 영향

  • Shin, Eun-Myoung (National Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Kim, Dong-Hyun (College of Pharmacy Kyung Hee University) ;
  • Kwon, Young-Bok (Atomaru Co., Gapyeong-gun) ;
  • Kim, Yeong-Shik (National Products Research Institute, College of Pharmacy, Seoul National University)
  • 신은명 (서울대학교 약학대학 천연물과학연구소) ;
  • 김동현 (경희대학교 약학대학) ;
  • 권영복 ((주)아토마루) ;
  • 김영식 (서울대학교 약학대학 천연물과학연구소)
  • Published : 2006.09.30
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Abstract

The effect of aqueous extracts of medicinal plants $AMP-365^{TM}$ was tested for immune system regulating activity based on anti-inflammatory activity, anti-oxidant, macrophage proliferation and T-lymphocyte proliferation activity. $AMP-365^{TM}$ dose-dependently increased proliferation of RAW264.7 macrophage cells and its nitric oxide production as well as DPPH radical scavenging activity. On the other hand, T-lymphocyte proliferation activity was decreased on dose-dependent manner. Passive cutaneous anaphylaxis reaction was alleviated by 49% by administering 250 mg/kg of $AMP-365^{TM}$. The results suggest that $AMP-365^{TM}$ can be beneficial in the treatment of immediate allergic reactions as an adjuvant supplement material.

Keywords

References

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