Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Estrogenic Activity of Furanocoumarins Isolated from Angelica dahurica

  • Piao, Xiang-Lan (School of Pharmaceutical Sciences, Peking University) ;
  • Yoo, Hye-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Kim, Hyun-Young (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kang, Tak-Lim (College of Oriental Medincine, Taejon University) ;
  • Hwang, Gwi-Seo (College of Oriental Medicine, Kyungwon University) ;
  • Park, Jeong-Hill (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
  • Published : 2006.09.01
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Abstract

In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with $EC_{50}$ values of 1.1 and $0.8\;{\mu}g/mL$, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.

Keywords

References

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