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The Pharmaceutical Society of Korea (대한약학회)
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Antifungal Effect of Amentoflavone derived from Selaginella tamariscina

  • Jung, Hyun-Jun (Department of Microbiology, College of Natural Sciences, Kyungpook National University) ;
  • Sung, Woo-Sang (Department of Microbiology, College of Natural Sciences, Kyungpook National University,Agro-Biotechnology Education Center, Kyungpook National University) ;
  • Yeo, Soo-Hwan (The Center for Traditional Microorganism Resources (TMR), Keimyung University) ;
  • Kim, Hyun-Soo (The Center for Traditional Microorganism Resources (TMR), Keimyung University) ;
  • Lee, In-Seon (The Center for Traditional Microorganism Resources (TMR), Keimyung University) ;
  • Woo, Eun-Rhan (College of Pharmacy, Chosun University) ;
  • Lee, Dong-Gun (Department of Microbiology, College of Natural Sciences, Kyungpook National University)
  • Published : 2006.09.01
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Abstract

Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.

Keywords

References

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