Journal of Acupuncture Research
- Volume 23 Issue 2
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- Pages.139-157
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- 2006
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
The Inhibitory Effects of Bee Venom and Melittin on the Proliferation of Vascular Smooth Muscle Cells
- Ha, Seong-Jong (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyungwon University) ;
- Song, Ho-Sueb (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyungwon University)
- Published : 2006.04.20
Abstract
In the present study, I have investigated the bee venom (BV) and melittin (a major component of BV) -mediated anti-proliferative effects, and defined its mechanisms of action in cultured rat aortic vascular smooth muscle cells (VSMCs). BV and melittin
Keywords
- Bee venom;
- Melittin;
- VSMCs;
- Proliferation;
- Apoptosis;
- $NF-{\kappa}B$;
- $I{\kappa}B$;
- Akt;
- ERK1/2;
- p53;
- Bcl-2;
- Bax;
- Active Caspase-3