Journal of Acupuncture Research
- Volume 23 Issue 2
- /
- Pages.125-137
- /
- 2006
- /
- 2586-288X(pISSN)
- /
- 2586-2898(eISSN)
Prevention of Collagen-induced Arthritis in Mice by Deer Antler Extract(DAE)
- Lee, A-Ram (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
-
Lee, Seung-Deok
(Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
-
Kim, Kap-Sung
(Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
- Kim, Woo-Young (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
-
Kim, Kyung-Ho
(Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University)
- Published : 2006.04.20
Abstract
Objectives : The effect of water extract of the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong), a traditional immuno-suppressive and immuno-activating Korean oriental medicine, on collagen-induced arthritis (CIA) mice model was studied. Identification of common Nokyong capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. Methods : Nokyong has shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of DAE on collagen-induced arthritis in mice. Results : In three independent experiments mice given DAE in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice given no DAE in water (84% to 100%). The arthritis index also was significantly lower in DAE-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2 (Cox-2),
Keywords
- type II collagen-induced arthritis;
- Rheumatoid arthritis;
- deer antler extract;
- Pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong);
- tumor necrosis factor ${\alpha}$;
- neutral endopeptidase;
- cyclooxygenase