대한본초학회지 (The Korea Journal of Herbology)

  • 제21권1호
  • /
  • Pages.17-24
  • /
  • 2006
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

당귀(當歸)와 황기(黃芪)의 배합 변화가 DPPH 자유기 소거에 미치는 영향 연구

Compositions of Astragali Radix and Angelicae Radix by DPPH Radical Scavenging Activity

  • 강순아 (서울벤처정보대학원대학교 발효식품과학과) ;
  • 오명숙 (경희대학교 한의과대학 처방제형학교실) ;
  • 김도림 (경희대학교 한의과대학 처방제형학교실) ;
  • 강지웅 (경희대학교 한의과대학 처방제형학교실) ;
  • 김원남 (경희대학교 한의과대학 처방제형학교실) ;
  • 박은화 (경희대학교 한의과대학 처방제형학교실) ;
  • 장문석 (하버드대학교 의과대학 소아병원) ;
  • 박성규 (경희대학교 한의과대학 처방제형학교실)
  • Kang, Soon-Ah (Dept. of Fermented Food Science, Seoul University of Venture & Information) ;
  • Oh, Myung-Sook (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Do-Rim (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kang, Ji-Ung (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Won-Nam (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Eun-Hwa (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Chang, Mun-Seog (Dept. of Medicine, Division of Newborn Medicine, Children's Hospital and Harvard Medical School) ;
  • Park, Seong-Kyu (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
  • 발행 : 2006.03.30
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초록

Objectives : This study was conducted to compare antioxidant activity of ratio-related Angelicae Radix and Astragali Radix compositions by DPPH radical scavenging activity. Methods : The species of Angelicae Radix was compared as Angelica gigas, A. sinensis and A. acutiloba. Then various compositions of Angelicae Radix with Astragali Radix were prepared with different ratio. Diphenyl-picryl-hydrazyl (DPPH) radical scavenging activity was measured after 10, 20 and 30 minutes. Each extracts were tested by 1, 5, 10, 50, 100, 500 and 1,000 ${\mu}g/ml$ concentrations. Results : The results showed that Angelica gigas, A. sinensis and A. acutiloba scavenged DPPH radical with 66.8, 61.7 and 56.7% in 1,000 ${\mu}g/ml$ concentration, respectively. According to this result, Angelicae Radix and Astragali Hadix compositions with 100:0, 10:1, 5:1, 3:1, 1:1, 1:3, 1:5, 1:10 and 0:100 ratio were scavenged DPPH radical with 56.3, 49.9, 61.2, 55.7, 54.7, 55.0, 52.8 ,md 50.2% in 1,000 ${\mu}g/ml$ concentration, respectively. The extract of Angelicae Radix and Astragali Radix compositions with 100:0, 10:1, 5:1, 3:1, 1:1, 1:3, 1:5, 1:10 and 0:100 ratio scavenged DPPH radical with the $IC_{50}$ being 85,21, 1016.26, 656.51, 785.67 and 956.74 ${\mu}g/ml$ respectively. Conclusion : In conclusion, the extract of Angelicae Radix and Astragali Radix compositions with 1:1 ratio showed dose-dependent DPPH radical scavenging activity.

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