Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effects of Poncirus trifoliata Pharmacopuncture on plasma lipid composition and concentration of $TNF-{\alpha}$ and IL-6 in rats fed high fat diet

지각(枳穀) 약침이 고지방 식이 급여 흰쥐의 혈액 내 지질구성과 $TNF-{\alpha}$ 및 IL-6농도에 미치는 영향

  • Lee, Jong-Wook (Dept. of Meridian & Acupoint,, College of Oriental Medicine, Sangji University) ;
  • Lee, Ji-Hyang (Dept. of Bio-industry and Technology. Sangji University) ;
  • Lee, Eun (Dept. of Bio-industry and Technology. Sangji University) ;
  • Lee, Joon-Moo (Dept. of Meridian & Acupoint,, College of Oriental Medicine, Sangji University)
  • 이종욱 (상지대학교 한의학과 경혈학교실) ;
  • 이지향 (상지대학교 바이오산업공학과) ;
  • 이은 (상지대학교 바이오산업공학과) ;
  • 이준무 (상지대학교 한의학과 경혈학교실)
  • Published : 2006.03.27
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Abstract

Objective : To investigate the effects of Poncirus trifoliata Pharmacopuncture on lowering lipid and contents of serum tumor necrosis $factor-{\alpha}$ $(TNF-{\alpha})$ and interleukin-6 (IL-6) in hyperlipidemic rats. Methods : Triglyceride, total cholesterol, $TNF-{\alpha}$, and IL-6 levels in Poncirus trifoliata Pharmacopuncture groups were compared with those in the control group. Results : Concentration of triglyceride and total cholesterol in plasma was decreased in the Poncirus trifoliata Pharmacopuncture groups. In Poncirus trifoliata Pharmacopuncre groups, plasma LDL-cholesterol showed a lower value and HDL-cholesterol showed a higher value than those of the control group. Contents of $TNF-{\alpha}$ was decreased in the Poncirus trifoliata Pharmacopuncture groups. Contents of IL-6, however, were not significantly different. Conclusions : The results suggest that Poncirus trifoliata Pharmacopuncture may have an impact on lipid metabolism to potentially prevent development of diabetes mellitus and accompanying cerebrovascular diseases.

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