Bioinformatics and Biosystems
- Volume 1 Issue 1
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- Pages.17-27
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- 2006
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- 1738-9798(pISSN)
In Vivo Reporter Gene Imaging: Recent Progress of PET and Optical Imaging Approaches
- Min, Jung-Joon (Department Nuclear Medicine, Chonnam National University Medical School, Laboratory of In Vivo Molecular Imaging, Institute for Molecular Photonic Imaging Research, Chonnam National University Hwasun Hospital)
- Published : 2006.02.28
Abstract
Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of molecular imaging biological research. These tools have been validated recently in variety of research models, and have been shown to provide continuous quantitative monitoring of the location(s), magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of radionuclide, magnetic resonance, and optical imaging technologies as they have been used in imaging gene delivery and gene expression for molecular imaging applications. The studies published to date demonstrate that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human diseases.
Keywords
- Molecular imaging;
- Positron Emission Tomography;
- Magnetic Resonance Imaging;
- Optical Imaging;
- Reporter gene;
- Gene expression