Bulletin of the Korean Chemical Society

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Asymmetric Cyanosilylation of Aldehydes by Chiral Ti-TADDOL Complex

  • Published : 2006.10.20
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Abstract

A variety of chiral cyanohydrins were readily prepared from aldehydes with TMSCN under the influence of chiral titanium complex formed in situ from $Ti(O^iPr)_4$/TADDOL(I) in the presence of $Ph_3PO$ as additive. The double activation method produces trimethylsilylethers in excellent yield (95%) with moderate enantiomeric excess.

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References

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