Bulletin of the Korean Chemical Society

  • 제27권10호
  • /
  • Pages.1638-1640
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  • 2006
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Asymmetric Cyanosilylation of Aldehydes by Chiral Ti-TADDOL Complex

  • 발행 : 2006.10.20
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초록

A variety of chiral cyanohydrins were readily prepared from aldehydes with TMSCN under the influence of chiral titanium complex formed in situ from $Ti(O^iPr)_4$/TADDOL(I) in the presence of $Ph_3PO$ as additive. The double activation method produces trimethylsilylethers in excellent yield (95%) with moderate enantiomeric excess.

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참고문헌

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피인용 문헌

  1. Solvent-free Cyanosilylation of Carbonyl Compounds Catalyzed by NbCl5 vol.28, pp.7, 2007, https://doi.org/10.5012/bkcs.2007.28.7.1167
  2. Asymmetric Cyanosilylation of Aldehydes by Chiral Ti-TADDOL Complex. vol.38, pp.18, 2006, https://doi.org/10.1002/chin.200718079
  3. Metal catalyzed asymmetric cyanation reactions vol.252, pp.5, 2006, https://doi.org/10.1016/j.ccr.2007.09.010
  4. Use of TADDOLs and their derivatives in asymmetric synthesis vol.64, pp.45, 2008, https://doi.org/10.1016/j.tet.2008.08.029
  5. Recent Progress in the Chemically Catalyzed Enantioselective Synthesis of Cyanohydrins vol.2010, pp.25, 2006, https://doi.org/10.1002/ejoc.201000462