Archives of Pharmacal Research

  • 제28권2호
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  • Pages.172-176
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  • 2005
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Butyrylcholinesterase Inhibitory Guaianolides from Amberboa ramosa

  • Khan Sher Bahadar (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Haq Azhar-ul (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Perveen Shagufta (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Afza Nighat (Pharmaceutical Research Centre, PCSIR Labs Complex Karachi) ;
  • Malik Abdul (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Nawaz Sarfraz Ahmad (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Shah Muhammad Raza (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Choudhary Muhammad lqbal (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi)
  • 발행 : 2005.02.01
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초록

Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as $8{\alpha}$-hydroxy-$11{\beta}$-methyl-$1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H,\;11{\alpha}H-guai-10(14)$, 4(15)-dien-6, 12-olide(2), $3{\beta},\;8{\alpha}-dihydroxy-11{\alpha}-methyl-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H,\;11{\beta}H-guai-10(14)$, 4(15)-dien-6, 12-olide (2), $3{\beta},\;4{\alpha},\;8{\alpha}-trihydroxy-4{\beta}(hydroxymethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide (3), $3{\beta},\;4{\alpha},\;8{\alpha}-trihydroxy-4{\beta}-(chloromethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide(4), $3{\beta},\;4{\alpha},\;dihydroxy-4{\beta}-(hydroxymethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide(5), $3{\beta},\;4{\alpha}-dihydroxy-4{\beta}-(chloromethyl)-8{\alpha}-(4-hydroxymethacrylate)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.

키워드

참고문헌

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