Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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Development of Proteomics and Applications of Proteomics in Toxicology

  • Jung, Woon-Won (MyGene Bioscience Institute) ;
  • Huh, Yoon-Ee (Environmental Toxico-Genomic and Proteomic Center, College of Medicine, Korea University) ;
  • Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science and Technology) ;
  • Lee, Eun-Il (Department of Preventive Medicine, College of Medicine, Korea University) ;
  • Sul, Dong-Geun (Graduate School of Medicine, Korea University)
  • Published : 2005.03.31
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Abstract

Proteomics has recently received intense scientific interest after the completion of the Human Genome Project, because this genome-based high technology allows to search new drug targets or diagnostic markers. Many proteome projects including Human plasma proteome projects (HPPP), Human liver proteome projects (HLPP), Human brain proteome projects (HBPP), and Mouse and Rat Proteome Project (MRPP) have been carried out and proteomic analytical techniques have been developed in second dimensional electrophoresis (2-DE) and LC/MS system. This powerful method has been applied in toxicology producing a new term "Toxicoproteomics". In this review, recent proteome projects, proteomic technologies, and toxicoproteomics will be discussed.

Keywords

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