Genomics 시대의 사상체질의학

Sasang Constitutional Medicine in the Genomics Era

  • 박화용 (한국한의학연구원 의료연구부) ;
  • 윤유식 (한국한의학연구원 의료연구부) ;
  • 김종열 (한국한의학연구원 의료연구부)
  • Park Hwa-Yong (Department of Medical Research, Korea Institute of Oriental Medicine) ;
  • Yoon Yoo-Sik (Department of Medical Research, Korea Institute of Oriental Medicine) ;
  • Kim Jong-Yeol (Department of Medical Research, Korea Institute of Oriental Medicine)
  • 발행 : 2005.12.01

초록

It is over 100 years after Lee Je Ma has proposed concept of the Sasang constitutional medicine in his book DongEuiSooSeBoWon in 1894. As well known, this concept describes four constitution of Taeyang, Taeum, Soyang, and Soeum which are deals with physical body status and shape, desease and symptoms, personal characters, and organ function. In these days there are growing needs to elucidate this Sasang concept by the scientific manner, especially by biological tools. However there are no genes revealed related to the Sasang and moreover it is not easy to give a biological evidence for the Sasang constitution. Here are some considerations about the brief history of biological research on the Sasang constitution, and some prospectives of how to do to find genes of Sasang, and which to be done for what is about Sasang.

키워드

참고문헌

  1. Venter, J.C. et al. The sequence of the human genome. Science. 291(5507):1304-1351, 2001.
  2. Altschuler, D., Brooks, L.D., Chakravarti, A., Collins, F.S., Daly, M.J., Donnelly, P. International HapMap Consortium. A haplotype of the human genome. Nature. 437(7063):1299-1320, 2005.
  3. 이제마. 동의수세보원. 보원계, 함흥, 1900.
  4. 김대윤, 이재원, 김달래. 사상체질의 유전성 검토에 대한 통계적 연구. 사상체질의학회지. 11(1):159-167, 1999.
  5. 이수헌, 윤유식, 김홍기, 김종열, 부모-자식간 사상체질 분포에 대한 임상연구. 동의병리생리학회지. 18(6):1904-1907, 2004.
  6. Botstein, D., White, R.L., Skolnick, M., Davis, R.W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics. 32(3):314-331, 1980.
  7. Mullis, K., Faloona, F., Scharf, S., Saiki, R., Horn, G., Erlich, H. Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. Cold Spring Harbor Symposia on Quantitative Biology. Pt1:263-273, 1986.
  8. Mermer. B., Colb, M., Krontiris, T.G. A family of short, interspersed repeats is associated with tandemly repetitive DNA in the human genome. Proceedings of the National Academy of Science of the USA. 84(10):3320-3324, 1987.
  9. Nakamura, Y., Leppert, M., O'Connell, P., Wolf, R., Holm, T., Culver, M., Martin, C., Fujimoto, E., Hoff, M., Kumlin, E. Variable number of tandem repeat (VNTR) markers for human gene mapping. Science. 235(4796):1616-1622, 1987.
  10. 김민희, 김경석, 지상은, 최선미, 조동욱. 유전적 분석법에 의한 사상체질의 연구. 사상체질의학회지. 11(1):169-183, 1999.
  11. 조동욱, 안선경, 김도균, 김대원, 지상은, 이의주, 홍석철, 고병희, 조황성. Amp-FLP을 이용한 사상체질의 유전적 분석 연구. 사상의학회지. 9(2):163-173, 1997.
  12. 옥윤영, 김종관, 한병삼, 김경요, 고기덕. 클루타티온 S-전환 효소 다형성과 뇌혈관질환 및 사상체질 사이의 관련성에 관한 연구. 사상체질학회지. 14(1):123-131, 2002.
  13. 한성규, 지상은, 최선미. HLA typing을 이용한 체질유전자 분석에 관한 연구. 사상체질의학회지. 13(1):97-103, 2001.
  14. 하만수, 고병희, 송일병. 사상체질과 HLA type과의 상관성에 관한 연구. 사상체질학회지. 14(1):90-99, 2002.
  15. 이수경, 이성진, 송일병. 사상체질집단의 ADPRT gene 3'UTR region의 단일염기다형성 연구. 사상체질학회지. 14(2):90-97, 2002.
  16. 주종천, 배영춘, 권덕윤, 김경요, 김일환. 뇌경색 환자의 안지오텐신 전환효소 유전자 다형성과 사상체질. 사상체질학회지. 14(1):132-139, 2002.
  17. 최승훈, 임용빈, 이준우, 김홍열, 강철훈. 사상체질유형과 ACE(angiotensin converting enzyme) 유전자 Type(polymorphism)과의 상관관계. 사상의학회지. 10(2):283-290, 1998.
  18. 이수경, 송일병. 사상체질의 유전적 다형성 연구-MTHFR의 단일염기다형성을 중심으로-. 사상체질의학회지. 13(2):177-181, 2001.
  19. 한성규, 지상은, 최선미. 체질유전자 분석에 관한 연구. 사상체질학회지. 15(1):109-117, 2003.
  20. 김선형, 김희정, 홍정미, 윤유식, 고병희, 최선미. 사상체질과 아토피성 질환 유전자의 다형성(IL-4 polymorphism)에 관한 연관성 연구. 사상체질학회지. 14(2):98-105, 2002.
  21. 하만수, 고병희, 송일병. 유전자를 이용한 체질유형감별의 방법론에 관한 고찰. 사상체질의학회지. 11(2):185-194, 1999.
  22. Montgomery, H.E., Marshall, R., Hemingway, H., Myerson, S., Clarkson, P., Dollery, C., Hayward, M., Holliman, D.E., Jubb, M., World, M., Thomas, E.L., Brynes, A.E., Saeed, N., Barnard, M., Bell, J.D., Prasad, K., Rayson, M., Talmud, P.J., Humphries, S.E. Human gene for physical performance. Nature. 393(21):221-222, 1998.
  23. Kim, K.S., Cho, D.Y., Kim, Y.J., Choi, S.M., Kim, J.Y., Shin, S.U., Yoon, Y.S. The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation. Biochimica et Biophysica Acta. 1741(1-2):149-155, 2005.
  24. Pastinen, T., Kurg, A., Metspalu. A., Peltonen, L., Syvanen, A.C. Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays. Genome Research. 7(6):606-614, 1997.
  25. Barinaga, M. Will 'DNA chip' speed genome initiative? Science. 253(5027):1489, 1991.
  26. Hacia, J.G., Woski, S.A., Fidanza, J., Edgemon, K., Hunt, N., McGall, G., Fodor, S.P., Collins, F.S. Enhanced high density oligonucleotide array-based sequence analysis using modified nucleoside triphosphates. Nucleic Acids Resesearch. 26(21):4975-4982, 1998.
  27. Gunderson, K.L., Steemers, F.J., Lee, G., Mendoza, L.G., Chee, M.S. A genome-wide scalable SNP genotyping assay using microarray technology. Nature Genetics. 37(5):549-554, 2005.
  28. Um, J.Y., Joo, J.C., Kim, K.Y., Lee, K.M. and Kim, H.M. Angiotensin converting enzyme gene polymorphism and traditional Sasang classification in Koreans with cerebral infarction. Hereditas 138:166-171, 2003.
  29. Um, J.Y., Kim, H.M., Park, H.S., Joo, J.C., Kim, K.Y., Kim, Y.K. and Hong, S.H. Candidate genes of cerebral infarction and traditional classification in Koreans with cerebral infarction. Intern J. Neuroscience. 115:743-756, 2005.
  30. Kim, J.W., Seo, J.C. and J., T.Y. Genetic polymorphism of interleukin 10 gene and Sasang constitution in Bell's Palsy patients. Korean J. Oriental Physiology & Pathology. 19(2):515-519, 2005.
  31. Jeong, H.J., Hong, S.H., Park, H.J., Kweon, D.Y., Lee, S.W., Lee, J.D., Kim, K.S., Cho, K.H., Kim, H.S., Kim, K.Y. and Kim, H.M. Yangkyuk-Sanhwa-Tang induces changes in serum cytokines and improves outcome in focal stroke patients. Vascular Pharmacology. 39, pp 63-68, 2002.
  32. Jeong, H.J., Seo, S.Y., Noh, H.S., Park, H.S., Lee, J.D., Kim, K.S., Cho, K.H., Kim, K.Y. and Kim, H.M. Regulation of THl/TH2 cytokine production by Chungsim-Yeunja-Tang in patients with cerebral infarction. Immunopharmacology and Immubnotoxicology. 25(1):29-39, 2003.
  33. Choi, J.S., Jung, S.W., Ju, J.C., Lee, S.W., Kim, K.Y. and Kim, H.M. Cytokine production regulation in human astrocytes by a herbal combination (Yuldahansotang). Immunopharmacology and Immunotoxicology. 24(1):55-67, 2002.