YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Sterilization for Quality Control on the Content of Paeonol in Moutan Radicies Bark

품질 보증을 위한 멸균법이 목단피의 패오놀 함량에 미치는 영향

  • Lee, Yong-Soo (College of Pharmacy, Duksung Women's University) ;
  • Shin, Woon-Seob (College of Medicine, Kwandong University) ;
  • Cho, So-Yean (Division of Herbal Medicines Standardization, Korea Food and Drug Administration) ;
  • Ze, Keum-Ryon (Division of Risk Assessment, Korea Food and Drug Administration) ;
  • Lee, Hyo-Min (Division of Food and Drug Exposure Assessment, Korea Food and Drug Administration) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
  • 이용수 (덕성여자대학교 약학대학) ;
  • 신운섭 (관동대학교 의과대학) ;
  • 조소연 (식품의약품안전청 생약규격과) ;
  • 제금련 (식품의약품안전청 위해성평가과) ;
  • 이효민 (식품의약안전청 식의약품위해성과) ;
  • 정춘식 (덕성여자대학교 약학대학)
  • Published : 2005.01.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to develop the best methods to sterilize Moutan Root Bark which is frequently used as a herbal medicine, and known to have high susceptibility to m icrobial contamination. We used dry heat, gamma irradiation and alcohol gas treatment for sterilization, and evaluated these methods in terms of the followings; I) the efficacy of sterilization, and ii) the chemical alteration of a major component of the harbal medicines. Treatment with dry heat effectively got rid of contaminated microorganisms, and did not significantly alter the content of paeonol. However it seriously changed the color and morphology which are an essential criterion to estimate a measure of quality of medicinal herbs. Treatment with gamma irradiation showed a strong sterilizing effect, and no alteration of the content of paeonol, color and morphology. Alcohol gas treatment resulted in similar effects as those in gamma irradiation. Collectively, these results suggest that appropriate sterilizing methods to guarantee the microbial quality of this herbal medicine may be those using gamma irradiation or alcohol gas.

Keywords

References

  1. 보건복지부 대한보건공정서협회 : 대한약전 제8개정, 1111(2003)
  2. 한국생약학교수협의회 편저, 대한약사회 : 本草學, 191 (1995)
  3. Okubo, T., Nagai, F., Ushiyama, K.. Seto, T., Satoh, K. and Kano, I. : The inhibitory effects of moutan cortex and paeoniae radix on oxidative DNA damage by t-butylhydroquinone, phenolic antioxidant. Mutation Res. 379, S178 (1997)
  4. Umeda, M., Amagaya, S. and Ogihara, Y : Effects of certain herbal medicines on the biotransformation of arachidonic acid: a new pharmacological testing method using serum. J. Ethnopharmacol. 23, 91 (1988) https://doi.org/10.1016/0378-8741(88)90117-1
  5. 야마오키 루미 : 생약의 함유 방사능. 防菌防微誌 31, 373 (2003)
  6. 아타라시 쿠니오 : 생약의 미생물 관리. 防菌防微誌 31, 739 (2003)
  7. 야마세 유타카 : 생약의 전자선조사살균/멸균. 防菌防微誌 31, 745 (2003)
  8. 키무라 쇼 지로, 마사시 오쓰미 유우코 : 습열살균에 의한 생약 말의 미생물수, 색조, 지표성분의 변화. 防菌防微誌 31, 751 (2003)
  9. Brantner, A. and Lucke, W. : Influence of physical parameters on the germ-reducing effect of microwave irradiation on medicinal plants. Pharmazie 50, 762 (1995)
  10. Kimura, S., Taimatsu, M., Kodani, N., Ohnishi, T. and Okamoto, S. : Radiation sterilization of the crude drug 'glycyrrhiza'. Biocontrol. Sci. 2, 87 (1997) https://doi.org/10.4265/bio.2.87
  11. Ah, Y. C., Choi, Y., Kim, S. Y., Kim, S. H., Lee, K. S. and Byun, Y. : Effects of ethylene oxide gas sterilization on physical properties of poly(L-lactide)-poly (ethylene glycol)-poly(Llactide) rnicrospheres. J. Biomater. Sci. Polym. 12, 783 (2001) https://doi.org/10.1163/156856201750411666