The Effect of korean, Chinese and American Ginseng on Blood Pressure of Hypertensive Patients

한국삼, 중국삼, 서양삼이 고혈압 환자의 혈압에 미치는 영향

  • Lee Cha-ro (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University) ;
  • Lee Sang-Ho (Department of Internal Medicine of Bupyeong Serim Oriental Hospital) ;
  • Rhee Jun-Woo (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University) ;
  • Na Byong-Jo (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University) ;
  • Kim Tae-Hun (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University) ;
  • Jung Woo-Sang (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University) ;
  • Moon Sang-Ho (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University) ;
  • Cho Ki-Ho (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University) ;
  • Bae Hyung-Sup (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University) ;
  • Kim Young-Suk (Department of Cardiovascular and Neurologic Disease(Stroke Center) College of Oriental Medicine,Kyunghee University)
  • 이차로 (경희대학교 한의과대학 심계내과학교실) ;
  • 이상호 (부평 세림한방병원 내과) ;
  • 이준우 (경희대학교 한의과대학 심계내과학교실) ;
  • 나병조 (경희대학교 한의과대학 심계내과학교실) ;
  • 김태훈 (경희대학교 한의과대학 심계내과학교실) ;
  • 정우상 (경희대학교 한의과대학 심계내과학교실) ;
  • 문상관 (경희대학교 한의과대학 심계내과학교실) ;
  • 조기호 (경희대학교 한의과대학 심계내과학교실) ;
  • 배형섭 (경희대학교 한의과대학 심계내과학교실) ;
  • 김영석 (경희대학교 한의과대학 심계내과학교실)
  • Published : 2005.09.01

Abstract

Objectives : We conducted a randomized, double-blinded clinical trial to assess the anti-hypertensive effect of Ginseng and to know the difference of the effect according to it's growing districts md species by 24-hour ambulatory blood pressure measurement (ABPM). Methods : We allocated 96 hypertensive patients enrolled in this trial to Korean ginseng(KG), American ginseng (AG), Chinese ginseng (CG), and Korean red ginseng (KRG) groups by randomization. Each subject was administered 4.5mg/day of encapsulated ginseng for 4 weeks. We assessed anti-hypertensive effect, blood pressure variability using ABPM and toxicity by blood chemistry before and after treatment. We also evaluated changes of symptoms due to hypertension and adverse effect in all groups at the first visit, 2 weeks later and 4 weeks later. Results : Blood pressure after treatments showed significant decrease of systolic blood pressure (sBP) in the CG-group (p<0,05) and diastolic blood pressure (dBP) in the KRG-group (p<0.05). However, there were no significant changes of sBP (or dBP) after treatment in the other groups and no significant difference in changes of BP between before and after treatment among the 4 groups. Blood pressure variability in the CG-group showed significant decrease after treatment but not in the KRG-group. Symptoms such as headache or neck stiffness and heating sensation due to hypertension improved significantly in all groups, especially in the KRG-group. A3l patients had no adverse effect after treatment and there was no liver or kidney toxicity. Conclusions : CG and KRG seem to have anti-hypertensive effects, but there was no significantly different effect depending on growing district and species of Ginseng.

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