The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Pharmacological Action of Radix Scutellariae on Nicotine-Induced Locomotor Activity and C-Fos Expression in Rats.

황금의 니코틴 약물투여에 의한 유전자 발현과 행동적 변동에 미치는 약리작용

  • Lee Bom-Bi (Dept. of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Chae Youn-Byoung (Dept. of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Kwon Young-Kyu (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Yang Chae-Ha (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Mi-Ryeo (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Kwang-Jung (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Seo Yong-Min (Dept. of Pediatrics, Division of Korean Oriental Medicine, Dongguk University) ;
  • Kim Jang-Hyun (Dept. of Pediatrics, Division of Korean Oriental Medicine, Dongguk University) ;
  • Hahm Dae-Hyun (Dept. of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Lee Hye-Jung (Dept. of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Pyun Kwang-Ho (Dept. of Integrative Medicine, College of Medicine, The Catholic University of Korea) ;
  • Shim In-Sop (Dept. of Integrative Medicine, College of Medicine, The Catholic University of Korea)
  • 이봄비 (경희대학교 동서의학대학원 한의과학과 침구경락학전공) ;
  • 채윤병 (경희대학교 동서의학대학원 한의과학과 침구경락학전공) ;
  • 권영규 (대구한의대학교 한의과대학 생리학교실) ;
  • 양재하 (대구한의대학교 한의과대학 생리학교실) ;
  • 김미려 (대구한의대학교 한의과대학 생리학교실) ;
  • 김광중 (대구한의대학교 한의과대학 생리학교실) ;
  • 서영민 (동국대학교 한의과대학 한방병원 소아과) ;
  • 김장현 (동국대학교 한의과대학 한방병원 소아과) ;
  • 함대현 (경희대학교 동서의학대학원 한의과학과 침구경락학전공) ;
  • 이혜정 (경희대학교 동서의학대학원 한의과학과 침구경락학전공) ;
  • 변광호 (가톨릭대학교 의과대학 통합의학교실) ;
  • 심인섭 (가톨릭대학교 의과대학 통합의학교실)
  • Published : 2005.09.01
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Abstract

Objectives : Substantial evidence suggests that reinforcing effects of nicotine can be mediated by the mesolimbic dopaminergic system. It has been shown that repeated injections of nicotine produce an increase in locomotor activity and expression of the immediate-early gene, c-fos, in the dopaminergic target areas. Herbal medicine as a therapeutic intervention has been widely used for the treatment of mental dysfunction. Many studies have shown that Radix Scutellariae (RS) can affect the biochemical balance in the central nervous system. Tn order to investigate whether RS has an influence on nicotine-induced behavioral sensitization, we examined the effect of RS on nicotine-induced locomotor activity and c-fos expression in the striatum and nucleus accumbens utilizing the fos-tike immunohistochemistry (FLI). Methods : Male SD rats received RS (200mg/kg, i.p.) 30min before repeated daily injections of nicotine (0.4mg/kg, s.c.) for 7 days. This was followed by withdrawal for 3 days and one challenge for 1 day. Results : System challenge with nicotine produced a much larger increase in locomotor activity and accumbal FLI. Pretreatment with RS significantly inhibited nicotine-induced locomotor activity and FLI in the striatum and nucleus accumbens. Conclusions : These results demonstrate that reduction in locomotor activity by RS may be reflected by reduction of dopamine release and postsynaptic neuronal activity in the striatum and nucleus accumbens. Our results suggest that RS may have therapeutic effect on nicotine addiction.

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