Applied Biological Chemistry

  • 제48권4호
  • /
  • Pages.418-420
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  • 2005
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  • 2468-0834(pISSN)
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  • 2468-0842(eISSN)
한국응용생명화학회 (The Korean Society for Applied Biological Chemistry)
권호 표지

식용식물자원으로부터 활성물질의 탐색-XIV. 사자발쑥(Artemisia herba)의 전초로부터 flavonoid 화합물의 분리

Development of Biologically Active Compounds from Edible Plant Sources XIV. Isolation and Identification of Flavonoids from the Aerial Parts of Sajabalssuk (Artemisia herba)

  • 방면호 (강화군농업기술센터 특화작목연구소) ;
  • 김동현 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 유종수 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 이대영 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 송명종 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 양혜정 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 정태숙 (한국생명공학연구원 지질대사연구실) ;
  • 이경태 (경희대학교 약학대학 약품생화학교실) ;
  • 최명숙 (경북대학교 식품영양학과) ;
  • 정해곤 (강화군농업기술센터 특화작목연구소) ;
  • 백남인 (경희대학교 생명공학원 및 식물대사연구센터)
  • Bang, Myun-Ho (Ganghwa Agricultural R&D Center) ;
  • Kim, Dong-Hyun (The Graduate School of Biotechnology & Plant Metabolism Research Center) ;
  • Yoo, Jong-Su (The Graduate School of Biotechnology & Plant Metabolism Research Center) ;
  • Lee, Dae-Young (The Graduate School of Biotechnology & Plant Metabolism Research Center) ;
  • Song, Myoung-Chong (The Graduate School of Biotechnology & Plant Metabolism Research Center) ;
  • Yang, Hye-Joung (The Graduate School of Biotechnology & Plant Metabolism Research Center) ;
  • Jeong, Tae-Sook (National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Kyung-Tae (Department of Biochemistry, College of Pharmacy, Kyung-Hee University) ;
  • Choi, Myung-Sook (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Chung, Hae-Gon (Ganghwa Agricultural R&D Center) ;
  • Baek, Nam-In (The Graduate School of Biotechnology & Plant Metabolism Research Center)
  • 발행 : 2005.12.31
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초록

사자발쑥의 전초를 80% MeOH 용액으로 추출하고, 추출물을 EtOAc, n-BuOH 및 물로 분배, 추출하였다. 이 중 EtOAc 분획을 silica gel과 octadecylsilica gel(ODS) column chromatography로 정제하여 4종의 화합물을 분리하였다. 각 화합물의 화학구조는 NMR, MS 및 IR 등의 스펙트럼 데이터를 해석하여, eupatilin (1), jaceosidin (2), apigenin (3) 및 eupafolin (4)으로 동정하였다. 이들 중 eupatilin과 jaceosidin은 사자발쑥에서 분리, 보고 된 바 있으나 eupafolin과 apigenin은 처음 분리되었다.

In order to search for biologically active compounds from edible plant sources, the aerial parts of Sajabalssuk (Artemisia herba) were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and $H_2O$, successively. From the EtOAc fraction, four compounds were isolated through the repeated silica gel and ODS column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as eupatilin (1), jaceosidin (2), apigenin (3) and eupafolin (4). Among them, compounds 3 and 4 were isolated for the first time from Sajabalssuk (Artemisia herba).

키워드

참고문헌

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