Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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Malignant Melanoma of the Vagina: A Report of 2 Cases

질의 원발성 악성 흑색종: 증례보고

  • Kim, Ok-Bae (Department of Radiation Oncology, Dongsan Medical Center, School of Medicine, Keimyung University) ;
  • Kim, Jin-Hee (Department of Radiation Oncology, Dongsan Medical Center, School of Medicine, Keimyung University) ;
  • Jung, Young-Yeon (Department of Radiation Oncology, Dongsan Medical Center, School of Medicine, Keimyung University) ;
  • Cho, Chi-Heum (Department of Gynecology, Dongsan Medical Center, School of Medicine, Keimyung University) ;
  • Choi, Tae-Jin (Department of Bio-physics Medical Engineering, Dongsan Medical Center, School of Medicine, Keimyung University)
  • 김옥배 (계명대학교 의과대학 동산의료원 방사선종양학교실) ;
  • 김진희 (계명대학교 의과대학 동산의료원 방사선종양학교실) ;
  • 정영연 (계명대학교 의과대학 동산의료원 방사선종양학교실) ;
  • 조치흠 (계명대학교 의과대학 동산의료원 산부인과학교실) ;
  • 최태진 (계명대학교 의과대학 동산의료원 의공학교실)
  • Published : 2005.06.01
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Abstract

Primary malignant melanoma of the vagina is an extremely rare genital neoplasm occurring mainly on postmenopausal women. It has a worse prognosis than cutaneous melanomas, because of the high rate of loco-regional recurrences and rapid systemic dissemination. In the past, radical surgical extirpation as the primary management had been recommended to improve loco-regional control, and possibly overall survival. However, the prognosis was poor In spite of such a radical approache. Recently, more conservative treatment such as wide local excision combined with adjuvant high-dose fraction radiotherapy seems to have premising results. Primary radiation therapy could be served as an alternative to surgery for patients with lesion less than 3 cm in diameter. We report 2 cases of primary vaginal malignant melanoma treated with radiotherapy.

질에서 발생하는 원발성 악성 흑색종은 희귀한 질환으로, 높은 국소 재발률과 조기 전이로 인하여 매우 나쁜 예후를 보인다. 전통적으로 높은 국소 재발율과 낮은 생존율의 개선을 위하여 질 절제술, 골반 내용 제거술 및 서혜부 임파절제술과 같은 근치적 수술을 시행하였으나, 재발률 및 생존율의 개선에 실패하였다. 그러나 최근 광범위 국소 제거술 및 소분할조사법으로 근치적 수술과 유사하거나 향상된 생존율이 보고되고 있다. 또한 병소의 크기가 3 cm 이하인 경우는 일차적 방사선치료만으로도 수술적 절제술과 유사한 생존이 가능하다고 하였다. 저자들은 질에서 발생한 원발성 악성 흑색종에 방사선치료를 시행한 2예를 경험하였기에 문헌 고찰과 함께 보고하고자 한다.

Keywords

References

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