Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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LICHENOID DYSPLASIA ASSOCIATED WITH MULTIPLE LEUKOPLAKIA : A CASE REPORT

다발성 백반증을 동반한 태선양 이형성증

  • Ahn, Shin-Young (Department of Oral & Maxillofacial Surgery, College of Dentistry, Chosun University, BK 21 Project) ;
  • Moon, Chul-Woong (Department of Oral & Maxillofacial Surgery, College of Dentistry, Chosun University, BK 21 Project) ;
  • Yoon, Jung-Hoon (Department of Oral Pathology, College of Dentistry, Chosun University, BK 21 Project) ;
  • Kim, Su-Gwan (Department of Oral & Maxillofacial Surgery, College of Dentistry, Chosun University, BK 21 Project)
  • 안신영 (조선대학교 치과대학 구강악안면외과학교실, BK21 Project) ;
  • 문철웅 (조선대학교 치과대학 구강악안면외과학교실, BK21 Project) ;
  • 윤정훈 (조선대학교 치과대학 구강병리학교실, BK21 Project) ;
  • 김수관 (조선대학교 치과대학 구강악안면외과학교실, BK21 Project)
  • Published : 2005.12.31
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Abstract

Lichenoid dysplasia is a lesion similar to oral lichen planus with epithelial dysplasia. It can be clinically mistaken for oral lichen planus, but has histologic features of dysplasia and a true malignant predisposition. It is not a variant or transitional form of lichen planus but, instead, represents a distinct entity that has a true potential for malignant transformation. In addition to abnormal epithelial maturation and cytology, lichenoid dysplasia exhibits other histologic features that separate it from oral lichen planus. Lichenoid dysplasia and lichen planus share many clinical and microscopic features, leading to the frequent misdiagnosis of unrecognized lichenoid dysplasia as lichen planus. We experienced a case of lichenoid dysplasia in the oral mucosa. We treated this patient with surgical excision. The patient has now been followed for two months. It is important to recognize this precancerous condition and inspect the excision site and remaining oral mucosa during long-term follow-up.

Keywords

References

  1. Krutchkoff DJ, Eisenberg E : Lichenoid dysplasia : a distinct histopathologic entity. Oral Surg Oral Med Oral Pathol 30 : 308, 1985
  2. Eisenberg E, Krutchkoff DJ : Lichenoid lesions of oral mucosa:diagnostic criteria and their importance in the alleged relationship to oral cancer. Oral Surg Oral Med Oral Pathol 73 : 699, 1992 https://doi.org/10.1016/0030-4220(92)90013-G
  3. Krutchkoff DJ, Eisenburg E, Anderson C : Dysplasia of oral mucosa:a unified approach to paper evaluation. Mod Pathol 41 : 113, 1991
  4. Shiohara T : The lichenoid tissue reaction : an immunological perspective. Am J Dermatopathol 10 : 252, 1988
  5. Lovas JG, Harsanyi BB, Elgeneidy AK : Oral lichenoid dysplasia : a clinicopathologic analysis. Oral Surg Oral Med Oral Pathol 68 : 57, 1989 https://doi.org/10.1016/0030-4220(89)90115-1
  6. MacDonald DG, Rennie JS : Oral epithelial atypia in denture- induced hyperplasia, lichen planus, and squamous cell papilloma. Int J Oral Surg 4 : 40, 1975 https://doi.org/10.1016/S0300-9785(75)80056-1
  7. Axell T, Rundquist L : Oral lichen planus : a demographic study. Community Dent Oral Epidermiol 15 : 52, 1987 https://doi.org/10.1111/j.1600-0528.1987.tb00480.x
  8. Silverman S Jr, Gorsky M, Lozada-Nur F : A prospective follow-up study of 570 patients with oral lichen planus : persistence, remission, and malignant association. Oral Surg Oral Med Oral Pathol 60 : 40, 1985
  9. Pindborg JJ, Metha FS, Daftary DK et al : Prevalence of oral lichen planus among 7639 Indian villagers in Kerala, South India. Acta Derm Venereol 52 : 216, 1972
  10. Mollaoglu N : Oral lichen planus : a review. Br J Oral Maxillofac Surg 38:370, 2000 https://doi.org/10.1054/bjom.2000.0335
  11. Eisenberg E : Oral lichen planus : a benign lesion. J Oral Maxillofac Surg 58 : 1278, 2000 https://doi.org/10.1053/joms.2000.16629
  12. Barnard NA, Scully C, Eveson JW et al : Oral cancer development in patient in patients with oral lichen planus. J Oral Pathol Med 22 : 421, 1993 https://doi.org/10.1111/j.1600-0714.1993.tb00134.x
  13. Eisen D : The clinical features, malignant potential, and systemic associations of oral lichen planus : a study of 723 patients. J Am Acad Dermatol 46 : 207, 2002 https://doi.org/10.1067/mjd.2002.120452
  14. Silverman S Jr, Gorsky M, Lozada-Nur F et al : A prospective study of findings and management in 214 patients with oral lichen planus. Oral Surg Oral Med Oral Pathol 72 : 665, 1991 https://doi.org/10.1016/0030-4220(91)90007-Y
  15. Holmstrup P, Thorn JJ, Rindum J et al : Malignant development of lichen planus-affected oral mucosa. J Oral Pathol 17 : 219, 1988 https://doi.org/10.1111/j.1600-0714.1988.tb01528.x
  16. Duffey DC, Eversole LR, Abemayor E : Oral lichen planus and its association with squamous cell carcinoma : an update on pathogenesis and treatment implication. Laryngoscope 106 : 357, 1996 https://doi.org/10.1097/00005537-199603000-00022
  17. Fatahzadeh M, Rinaggio J, Chiodo T : Squamous cell carcinoma arising in an oral lichenoid lesion. J Am Dent Ass 135 : 754, 2004 https://doi.org/10.14219/jada.archive.2004.0302
  18. Keszler A, Cabrini RL : Histometric study of leukoplakia, lichen planus and carcinoma in situ of oral mucosa. J Oral Pathol 12 : 330, 1983 https://doi.org/10.1111/j.1600-0714.1983.tb00344.x
  19. Eisenberg E, Murphy GF, Krutchkoff DJ : Involucrin as a diagnostic marker in oral lichenoid lesions. Oral Surg Oral Med Oral Pathol 64 : 313, 1987 https://doi.org/10.1016/0030-4220(87)90011-9
  20. Nowell PC : Mechanism of tumor progression. Cancer Res 46 : 2203, 1986
  21. Renan MJ : How many mutations are required for tumorigenesis? Implication from human cancer data. Mol Carcinog 7 : 139, 1993 https://doi.org/10.1002/mc.2940070303
  22. Slaughter DP, Southwick HW, Smejkal : 'Field cancerization' in oral stratified squamous epithelium : Clinical implications of multicentric origin. Cancer 6 : 963, 1953 https://doi.org/10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q
  23. Chung KY, Mukhopadhyay T, Jhingook K et al : Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract. Cancer Res 53 : 1676, 1993