Journal of the Optical Society of Korea

Optical Society of Korea (한국광학회)
권호 표지
DOI QR코드

DOI QR Code

Noninvasive Hematocrit Monitoring Based on Parameter-optimization of a LED Finger Probe

  • Yoon, Gil-Won (Department of Electronic & Information, Seoul National University of Technology) ;
  • Jeon, Kye-Jin (u-Health Project Team, Samsung Advanced Institute of Technology Kiheung)
  • Received : 2005.07.27
  • Published : 2005.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

An optical method of measuring hematocrit noninvasively is presented. An LED Light with multiple wavelengths was irradiated on fingernail and transmitted light from the finger was measured to predict hematocrit. A finger probe contained an LED array and detector. Our previous experience showed that prediction accuracy was sensitive to reliability of the finger probe hardware and we optimized the finger probe parameters such as the internal color, detector area and the emission area of a light source based on Design of Experiment. Using the optimized finger probe, we developed a hematocrit monitoring system and tested with 549 persons. For the calibration model with 368 persons, a regression coefficient of 0.74 and a standard deviation of 3.67 and the mean percent error of $8\%$ were obtained. Hematocrits for 181 persons were predicted. We achieved a mean percent error of $8.2\%$ where the regression coefficient was 0.68 and the standard deviation was 3.69.

Keywords

References

  1. R. McNichols and G. L. Cote, 'Optical glucose sensing in biological fluids : an overview,' J. Biomedical Optics, vol. 5, no. 1, pp. 5-16, 2000 https://doi.org/10.1117/1.429962
  2. J.G. Webster ed., Design of Pulse Oximeters, (Institute of Physics Publishing, Bristol and Philadelphia, 1997), pp. 124-143
  3. S. Yasuda, S. Itoh, K. Isobe, et al., 'New transcutaneous jaundice device with two optical paths,' J. Perinat. Med., vol. 31, pp. 81-88, 2003 https://doi.org/10.1515/JPM.2003.012
  4. K.J. Jeon, S-J Kim, K.K. Park, J-W Kim, and G. Yoon, 'Noninvasive total hemoglobin measurement,' J. of Biomedical Optics, vol. 7, no. 1, pp. 45-50, 2001 https://doi.org/10.1117/1.1427047
  5. S. Hahn, G. Yoon, G. Kim, and S-H Park, 'Reagentless determination of human serum components using infrared absorption spectroscopy,' Journal of the Optical Society of Korea, vol. 7, no. 4, pp. 240-244, 2003 https://doi.org/10.3807/JOSK.2003.7.4.240
  6. C. Choi, K-S Soh, S.M. Lee, and G. Yoon, 'Propagation of light along an Acupuncture meridian,' Journal of the Optical Society of Korea, vol. 7, no. 4, pp. 245-248, 2003 https://doi.org/10.3807/JOSK.2003.7.4.245
  7. R. F. Schmidt and G. Thews eds. Human Physiology, (Springer-Verlag Berlin Heidelberg, 1993), Chapt. 18
  8. S. M. Hopfer, F.L. Nadeau, M. Sundra, and G. S. Makowski, 'Effect of protein on hemoglobin and hematocrit assays with a conductivitity-based point-of-care testing device : comparison with optical methods,' Annals of clinical & Laboratory Science, vol. 34, pp. 75- 82, 2004
  9. H. Kanashima, T. Yamane, T. Takubo, T. Kamitani, and M. Hino, 'Evaluation of noninvasive hemoglobin monitoring for hematological disorders,' J. of Clin. Lab. Anal., vol. 19, pp. 1-5, 2005 https://doi.org/10.1002/jcla.20046
  10. D. Dvir, D. Geva, O. Amir, I. Fine, E. Moanshkin, G. Fostick, and E. Segal, 'Evaluation of a noninvasive hemoglobin and hematocrit monitoring device,' Critical Care, vol. 9, suppl 1, P333, 2005 https://doi.org/10.1186/cc3396
  11. G. Yoon, S-J Kim, K. J. Jeon, 'Robust design of finger probe in non-invasive total haemoglobin monitor,' Medical & Biological Engineering & Computing, vol. 43, no. 1, pp. 121-125, 2005 https://doi.org/10.1007/BF02345132
  12. O.Wieben, Saturation versus normalized ratio, J.G. Webster ed., Design of Pulse Oximeters, (Institute of Physics Publishing, Bristol and Philadelphia, 1997), chapter 4.4
  13. V. Twersky, 'Absorption and multiple scattering by biological suspensions,' J. Opt. Soc. Am., vol. 60, pp. 1084-1093, 1970 https://doi.org/10.1364/JOSA.60.001084

Cited by

  1. Analyzing near-infrared scattering from human skin to monitor changes in hematocrit vol.16, pp.9, 2011, https://doi.org/10.1117/1.3625283