약학회지 (YAKHAK HOEJI)

  • 제49권4호
  • /
  • Pages.335-339
  • /
  • 2005
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  • 0377-9556(pISSN)
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  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

3-메톡시-6-알릴치오피리다진의 사람 췌장암 세포 사멸작용

Induction of Apoptosis by 3-Methoxy-6-Allylthiopyridazine in Human Pancreatic Cancer Cells

  • 강영신 (미국 국립보건원 세포생리학교실) ;
  • 서연원 (중앙대학교 의약식품대학원) ;
  • 권순경 (덕성여자대학교 약학대학) ;
  • 정춘식 (덕성여자대학교 약학대학) ;
  • 이용수 (덕성여자대학교 약학대학)
  • Kang Young Shin (Department of Cell Physiology, NHLBI, National Institutes of Health) ;
  • Suh Yeon Won (Graduate School of Food and Drug Administration, Chung-Ang University) ;
  • Kwon Soon-Kyoung (College of Pharmacy, Duksung Women's University) ;
  • Jeong Choon Sik (College of Pharmacy, Duksung Women's University) ;
  • Lee Yong Soo (College of Pharmacy, Duksung Women's University)
  • 발행 : 2005.08.01
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초록

In this study we investigated the effect of 3-methoxy-6-allylthiopyridazine on cell growth in BxPC3 and PANC1 human pancreatic cancer cells. The treatment with 3-methoxy-6-allylthiopyridazine for 48h decreased cell viability and induced apoptotic cell death in a dose-dependent manner, assessed by using the MTT assay and the flow cytometry, respectively. These results suggest that 3-methoxy-6-allylthiopyridazine may be a good candidate for the therapeutic management of human pancreatic cancers.

키워드

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