Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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The Effects of Dietary Supplements Included Green Tea, Buckwheat and Grape Leaf Extract on Lipid Metabolism and on Regression of Fatty Streak Lesions in F1B Golden Syrian Hamsters Fed the Atherogenic Diet

녹차, 메밀 및 포도잎 추출물 첨가식이가 동맥경화유발식이를 급여한 F1B Golden Syrian 햄스터의 지질대사와 대동맥의 지방 축적에 미치는 영향

  • Published : 2005.12.31
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Abstract

Effects of 5 and 10% dietary supplement tablets containing green tea, buckwheat, and grape leaf extracts on atherosclerosis, and plasma and hepatic lipid compositions in hamsters fed antherogenic diet [modified AIN-76A containing 10% coconut oil (w/w), 0.05% cholesterol] were examined. Compared to atherogenic diet only groups, addition of supplement to atherogenic diet-fed group significantly down-regulated triglyceride and total cholesterol levels in plasma and liver. F1B hamsters fed atherogenic diet had greater foam cell accumulation compared to control and those fed atherogenic diet with addition of supplement. Lipid metabolisms of plasma and liver increased with addition of supplement dose-dependently, whereas aortic lipid accumulation decreased. These results indicate tablets supplemented with green tea, buckwheat, and grape leaf extracts have potential to prevent cardiovascular diseases in golden Syrian hamsters.

7주령의 F1B golden Syrian 햄스터에게 동맥경화 유발식이에 녹차추출물, 메밀추출물 및 포도잎 추출물을 함유한 타블렛 제품을 각각 5%와 10%로 첨가하여 7주간 사육하였을 때 햄스터 체내의 지질성분과 대동맥 내에서의 지방의 축적 정도에 미치는 영향을 조사하였다. 실험 결과 녹차, 메밀, 포도잎 추출물을 함유한 타블렛 제품은 동맥경화유발식이를 섭취하는 햄스터의 혈중 중성지방과 총콜레스테롤치를 감소시켰고, 대동맥궁내에서의 지방의 축적을 예방하였고, 간장내 중성지방과 총콜레스테롤치를 감소시키는 것으로 나타났다. 특히 5%를 첨가한 군보다 10%를 첨가한 군에서 더 높은 효과를 나타내어 농도 의존적인 경향을 보였다. 이러한 결과를 통해 녹차, 메밀 및 포도잎 추출물 분말을 이용하여 식이 보조제의 형태로 개발한 타블렛 제품이 동맥경화를 예방하는 식품으로써 효과가 있음을 확인할 수 있었다.

Keywords

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