Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Experimental research for the protective effect of Naoxingtong-containing serum on rat cerebral microvascular endothelial cells

  • Jun, Zhou (Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of TCM) ;
  • Jianyou, Guo (Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of TCM) ;
  • Jian, Guo (Shaanxi Xianyan Changfeng Pharmaceutics Company) ;
  • Lanfang, Li (Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of TCM) ;
  • Canghai, Li (Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of TCM) ;
  • Nan, Jiang (Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of TCM) ;
  • Shuying, Guo (Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of TCM) ;
  • Hairu, Huo (Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of TCM) ;
  • JiangTingliang, JiangTingliang (Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of TCM)
  • Published : 2005.06.30
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Abstract

The protective effect of Naoxingtong (NXT) on rat cerebral microvascular endothelial cell (rCMEC) was investigated. rCMEC was injured in vitro by incubating for 4 hours at 100% NO in a hypoxia chamber. After treated with NXT-containing serum, the cellular viability rate (90.3%) was significantly elevated when compared with that of control group and the inhibitive rate of lactic dehydrogenase activity (9.2%) was far lower than the control group with dose-dependent effect. The results indicate that NXT can increase viability of rCMEC, and protect cell membrane from injury during hypoxia.

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References

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