한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제13권2호
  • /
  • Pages.80-84
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  • 2005
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지

Cytotoxic Anthraquinones and Stilbenes from Reynoutria sachalinensis (Fr. Schm.) Nakai

  • Jin, Wenyi (College of Pharmacy, Chungnam Natl. Univ.) ;
  • Na, Min-Kyun (College of Pharmacy, Chungnam Natl. Univ.) ;
  • Song, Gyu-Yong (College of Pharmacy, Chungnam Natl. Univ.) ;
  • Lee, Young-Mi (Dept. of Oriental Pharmacy, College of Pharmacy, Wonkwang Univ.) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam Natl. Univ.)
  • 발행 : 2005.04.30
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초록

Five known anthraquinones, physcion (1), I-O-methylemodin (2), emodin (3), $physcion-8-O-{\beta},-D-glucopyranoside$ (5), $emodin-8-O-{\beta},-D-glucopyranoside$ (6) and two known stilbenes, trans-resveratrol (4), $trans-resveratrol-3-O-{\beta},-D-glucopyranoside$ (7) were isolated from MeOH extract of Reynoutria sachalinensis (Polygonaceae). All structures were unambiguously established by 1D and 2D NMR and MS data and the compounds were evaluated for their cytotoxicity against L1210, HL-60, BI6F10 tumor cell lines in MTT assay. Among the compounds, trans-resveratrol (4) exhibited significant cytotoxic activity with $IC_{50}$ values of 9.2, 6.7 and $9.8\;{\mu}g/ml$, against the test cell lines respectively, but compounds 1-3 exhibited the moderate cytotoxic activity.

키워드

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