Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Immunostimulant and Anti-Tumor Activity of Crude Extracts of Galium aparine L.

팔선초 물 추출물의 면역자극 및 항종양 활성

  • Yoon, Taek-Joon (Bio-Food and Drug Research Center, Konkuk University) ;
  • Lee, Chang-Kwon (Bio-Food and Drug Research Center, Konkuk University) ;
  • Park, Tae-Kyu (Bio-Food and Drug Research Center, Konkuk University,Department of Biotechnology, College of Biomedical and Health Science, Konkuk University) ;
  • Lee, Kwang-Ho (Bio-Food and Drug Research Center, Konkuk University,Department of Biotechnology, College of Biomedical and Health Science, Konkuk University)
  • 윤택준 (건국대학교 바이오식의약 연구센터) ;
  • 이창권 (건국대학교 바이오식의약 연구센터) ;
  • 박태규 (건국대학교 바이오식의약 연구센터,건국대학교 의료생명대학 생명공학) ;
  • 이광호 (건국대학교 바이오식의약 연구센터,건국대학교 의료생명대학 생명공학)
  • Published : 2005.12.30
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Abstract

We here demonstrate the evidence of increased anti-tumor and immunostimulating activities of crude extracts (GAL) from Galium. aparine L. In experimental lung metastasis of colon26-M3.1 carcinoma or B16-BL6 melanoma cells, prophylactically intravenous (i.v) administration of GAL significantly inhibited lung metastasis in a dose-dependant manner. In an in vitro cytotoxicity analysis, GAL at the concentration up to $500\;{\mu}g/ml$ did not affect the growth of B16-BL6 melanoma cells. In contrast, GAL showed the enhancement of splenocyte proliferating activity in a dose-dependent manner. Peritoneal macrophages stimulated with GAL produced various cytokines such as $1L-1{\beta},\;TNF-{\alpha},\;IFN-{\gamma}$ and IL-12. These data suggest that GAL has an antitumor activity to inhibit tumor metastasis, and its antitumor effects is associated with activation of nonspecific immnune related cells.

Keywords

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