The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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A Study on the Protective Effects of Siegesbeckiae Herba on Neurotoxicity Induced by N-methyl-D-aspartic acid(NMDA)

희렴(??)이 NMDA로 유발된 신경세포 손상에 미치는 효과

  • Lee, In (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Seong, Nak-Sull (National Crop Experiment Station, RDA) ;
  • Lee, Young-Jong (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
  • 이인 (경원대학교 한의과대학 본초학교실) ;
  • 성낙술 (농촌진흥청 작물과학원) ;
  • 이영종 (경원대학교 한의과대학 본초학교실)
  • Published : 2005.12.30
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Abstract

Objectives : Siegesbeckiae Herba's effect on the protection of nerve cells was tested, and the effects were compared between Siegesbeckia glabrescens Makino, the state of which is spica imported from China, and original Korean leaves of it. Methods : After damaging nerve cells by exposing them on NMDA (N-methyl-D-aspartic acid) and KA(kainic acid), Siegesbeckiae Herba's effect on cell death, inhibition rate, glutamate separation, and ROS(reactive oxygen species) production were examined. Results : 1. Siegesbeckiae Herba inhibited the cell death exposed to NMDA. 2. Siegesbeckiae Herba inhibited the amount of glutamate separated from nerve cells exposed to NMDA. 3. Siegesbeckiae Herba inhibited the production of ROS induced by NMDA. 4. Siegesbeckiae Herba did not inhibit the cell death exposed to KA. 5. Chinese Siegesbeckiae Spica had no inhibition effect on cell death. Conclusions : Siegesbeckiae Herba was effective in inhibiting the death of nerve cells exposed to NMDA, and in protecting nerve cells from various damages in nerve cell diseases. Because Chinese Siegesbeckiae Spica did not show such effects, it is necessary to closely examine those effects according to the used parts.

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