Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Korean Red Ginseng Significantly Slows CD4 T Cell Depletion over 10 Years in HIV-1 Infected Patients: Association with HLA

  • Cho, Young-Keol (Department of Microbiology, University of Ulsan College of Medicine) ;
  • Sung, Heungsup (Department of Microbiology, University of Ulsan College of Medicine) ;
  • Kim, Tai Kyu (Department of Microbiology, College of Medicine, The Catholic University of Korea) ;
  • Lim, Ji Youn (Department of Microbiology, University of Ulsan College of Medicine) ;
  • Jung, You Sun (Department of Microbiology, University of Ulsan College of Medicine) ;
  • Kang, Sang-Moo (Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine)
  • Published : 2004.12.01
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Abstract

We have shown that long-term intake of Korean red ginseng (KRG) delays disease progression in HIV-I infected patients. In the present study to investigate whether this slow progression was associated with protective human leukocyte antigen (HLA) alleles as well as with KRG-intake, we have performed clinical analysis of 31 HIV-1 infected patients who have been living for more than 10 years without any antiretroviral therapy. Average amount of KRG-intake over $130\;{\pm}16$ months was $4,797\;{\pm}4,921\;g$ and the annual decrease in CD4 T cell (AD) was $30\;{\pm}29{\mu}L$. We observed significant correlations among amount of KRG-intake, AD(r=-0.53, P < 0.01), and plasma HIV-1 RNA copy (r=-0.35, P < 0.05), along with a significant correlation between KRG-intake and HLA score AD(r=-0.49, P < 0.01), whereas there was no significant correlation between HLA score and AD or viral load. When the 31 patients were divided into 2 groups based on the amount of KRG-intake, the $AD(14/{\mu}L)$ in the 16 patients who had taken higher amounts of KRG was significantly less than that $(49/{\mu}L)$ in the 15 patients with a little or no KRG-intake (P < 0.01). These data indicate that KRG-intake sig­nificantly slows CD4 T cell depletion in HIV-1 infected patients.

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References

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