Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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The Prognostic Significance of Tumor Angiogenesis and Expression of Vascular Endothelial Growth Factor in Papillary Carcinomas of the Thyroid Gland

갑상선 유두상 암종에서 종양혈관형성 및 혈관내피성장인자 발현의 예후인자적 의의

  • Kang Hun-Dae (Department of Surgery, Inje University College of Medicine) ;
  • Kim Seong-Bae (Department of Surgery, Gupo Sung Sim Hospital) ;
  • Kim Tae-Hyun (Department of Surgery, Inje University College of Medicine) ;
  • Oh Sang-Hoon (Department of Surgery, Inje University College of Medicine) ;
  • Yoon Hye-Kyong (Department of Pathology, Inje University College of Medicine) ;
  • Kim Sang-Hyo (Department of Surgery, Inje University College of Medicine)
  • 강헌대 (인제대학교 의과대학 부산 백병원 외과학교실) ;
  • 김성배 (구포성심병원 외과) ;
  • 김태현 (인제대학교 의과대학 부산 백병원 외과학교실) ;
  • 오상훈 (인제대학교 의과대학 부산 백병원 외과학교실) ;
  • 윤혜경 (인제대학교 의과대학 병리과학교실) ;
  • 김상효 (인제대학교 의과대학 부산 백병원 외과학교실)
  • Published : 2004.11.01
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Abstract

Objectives: The purpose of this study was to evaluate for prognostic significance of VEGF expression and tumor angiogenesis in papillary carcinomas of the thyroid. Materials and Methods: The materials were 79 cases of papillary thyroid carcinomas, and age, sex, tumor size, multiplicity of tumor, capsular invasion, lymph node metastasis, recurrence, TNM stage, DeGroot stage and AMES scale were evaluated. An immunohistochemical stains for CD 34 to estimate microvessel density (MVD), and VEGF were done. MVD was defined as an average count of vessels per ${\times}400$ power field in the most vascularized area. VEGF expression was interpreted as 1+ and 2+ according to staining intensity and percentages of positive cells. Results: Mean score of MVD was $39.7{\pm}16.9.$ MVD were significantly higher in cases with capsular invasion (p=0.0001), lymph node metastasis (p=0.0001), TNM stage III (p=0.0022), DeGroot stage III (p=0.0163) and high risk group by AMES scale (p=0.0001). VEGF 2+ expression rate was significantly increased in cases with capsular invasion and lymph node metastasis (p=0.0006, p=0.0013), and in cases with TNM stage III, DeGroot stage III and high risk group by AMES scale (p=0.0236, p=0.0003, p=0.0293). In VEGF 2 + expression group, MVD was significantly higher than in VEGF 1 + group (p=0.0008), and MVD showed positive relation to VEGF 2 + expression (r=0.4616). Conclusion: VEGF expression and high MVD were significantly correlated to capsular invasion, lymph node metastasis, TNM stage III, DeGroot stage III and high risk group by AMES scale. The expression of VEGF and high MVD could be considered to be one of prognostic factor in papillary thyroid carcinomas.

Keywords

References

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