Korean Journal of Bronchoesophagology (대한기관식도과학회지)

The Korean Bronchoesophagological Society (대한기관식도과학회)
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Levels of Soluble Intercelluar Adhesion Molecule-1 and Total Sialic Acid in Serum of Patients with Oral Cavity Cancer and Laryngeal Cancer

진행된 구강암 및 후두암 환장의 혈청 Intercellular Adhesion Molecule-1(ICAM-1) 및 Sialic acid(SA)농도

  • Choi Seung-Hyo (Department of Otolaryngology, University of Ulsan College of Medicine) ;
  • Yun Doo Hwm (Department of Otolaryngology, University of Ulsan College of Medicine) ;
  • Kang Jin Wook (Department of Otolaryngology, University of Ulsan College of Medicine) ;
  • Kwan Hyun Ja (Department of Otolaryngology, University of Ulsan College of Medicine) ;
  • Lee Jae Dong (Department of Otolaryngology, University of Ulsan College of Medicine) ;
  • Park Jung Je (Department of Otolaryngology, University of Ulsan College of Medicine) ;
  • Nam Soon Yuhl (Department of Otolaryngology, University of Ulsan College of Medicine)
  • 최승효 (울산대학교 의과대학 이비인후과학교실) ;
  • 윤두환 (울산대학교 의과대학 이비인후과학교실) ;
  • 강진욱 (울산대학교 의과대학 이비인후과학교실) ;
  • 임현우 (울산대학교 의과대학 이비인후과학교실) ;
  • 권현자 (울산대학교 의과대학 이비인후과학교실) ;
  • 박정제 (울산대학교 의과대학 이비인후과학교실) ;
  • 남순열 (울산대학교 의과대학 이비인후과학교실)
  • Published : 2004.06.01
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Abstract

Adhesion molecules have been implicated in tumor progression. In this study, we aimed to investigate serum soluble intercellular adhesion molecule-1 (ICAM-1) and sialic acid (SA) levels in oral cavity cancer and laryngeal cancer and correlate their levels with cancer progression. Method : The sera from 31 patients with advanced oral cavity cancer (5 at stage III, 10 at stage IV) and advanced laryngeal cancer (1 at stage III, 15 at stage IV) were extracted before treatment. The concentrations of ICAM-1 was measured by Endogen kit (measured absorbance at 490nm) and the concentration of SA was measured by Roche kit (measured absorbance at 550nm). Respectively, gained data was compared with those from a control group (n=12). Result : Mean serum ICAM-1 and SA levels were found to be higher in oral cavity cancer group and laryngeal cancer group than control group. But statistical meaning was at SA (p<0.001, oral cavity cancer and laryngeal cancer versus control). Conclusion : These data reveal that the significant correlations serum SA level in advanced oral cavity cancer and laryngeal cancer. Serum ICAM-1 level was higher at advanced oral cavity cancer and laryngeal cancer than at control group but that was not significant.

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