Fisheries and Aquatic Sciences

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Effect of Parathion on Hematological Parameters in the Serum of a Male Bagrid Catfish (Pseudobagrus fulvidraco )

  • Cho Kyu-Seok (Department of Inland Fisheries Research Institute) ;
  • Park Jong-Ho (Department of Inland Fisheries Research Institute) ;
  • Kang Ju-Chan (Department of Aquatic Life Medicine, Pukyong National University)
  • Published : 2004.09.01
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Abstract

To evaluate the impact of parathion on aquatic organisms, a freshwater bagrid catfish (Pseudobagrus fulvidraco) was exposed to sublethal concentrations $(63,\;95,\;190\;and\;380\;{\mu}g/L)$ of parathion, organophosphorus pesticide for 30 days. Glucose level in the serum of the bagrid catfish was significantly increased than that of control groups in the $190\;{\mu}g/L$ concentration at 30 days and in the $380\;{\mu}g/L$ concentration after 10 days. Bilirubin level was significantly increased in the $190\;{\mu}g/L$ concentration at the end of the experiment. After 10 days, a significant differences of lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) activity increased in the ${\geq}190\;{\mu}g/L$ and $380\;{\mu}g/L$ groups. Though cholesterol concentration was stable, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities in serum were significantly reduced in the $190\;{\mu}g/L$ at 10 days and in the $380\;{\mu}g/L$ concentration at the end of the experiment. In conclusion, if P. fulvidraco was chronically exposed to ${\geq}190\;{\mu}g/L$ concentration of parathion, the hematological changes may be induced due to the stress response.

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References

  1. APHA, AWWA and WPCF. 1998. Standard Methods for the Examination of Water and Wastewater. 20th ed. American Public Health Association, 1532
  2. Asztalos, B. and J. Nemcsok. 1985. Effect of pesticides on the LDH activity and isoenzyme pattern of carp (Cyprinus carpio L.) sera. Comp. Biochem. Physiol., 82C, 217-219
  3. Asztalos, B., I. Nemcsok. R. Benedeczky, A. Gabriel, A. Sza and O.J. Refaie. 1990. The effects of pesticides on some biochemical parameters of carp (Cyprinus carpio L.). Arch. Environ. Contam. Toxicol., 19, 275-282 https://doi.org/10.1007/BF01056097
  4. Areechon, Nand J.A. Plumb. 1990. Sublethal effects of malathion on channel catfish, Ictalurus punctatus. Bull. Environ. Contam. Toxicol., 44, 435-442 https://doi.org/10.1007/BF01701226
  5. Beyer, J., M. Sandvik, K. Hylland, E. Fjeld, E. Egaas, E. Aas, J.U. Skaare and A. Goks$\phi$yr. 1996. Contaminant accumulation and biomarker responses in flounder (Platichthys flesus L.) and Atlantic cod (Gadus rnorhua L.) exposed by caging to polluted sedimerts in S$\phi$rfjorden, Norway. Aquat. Toxicol., 36, 75-98 https://doi.org/10.1016/S0166-445X(96)00798-9
  6. Bucher, F. and R. Hofer. 1990. Effects of domestic wastewater on serum enzyme activities of brown trout (Salrno trutta). Compo Biochem. Physiol., 97C, 381-385
  7. Butler, A.M and M. Murray. 1997. Biotransformation of parathicn in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidaticn. J. Pharm. Exp. Therap. 280, 966-973
  8. Boone, J.S and J.E. Chambers. 1997. Biochemical factors contributing to toxicity differences among cloropyrifos, parathion, and methyl parathion in mosquitofish (Garnbusia afjinis). Aquat. Toxicol., 39, 333-343 https://doi.org/10.1016/S0166-445X(97)00019-2
  9. Carlson, K and M. Ehrich. 1999. Organophorphorus compound- induced modification of SH-SY5Y human neuroblastoma mitochondrial transmembrane potential. Toxicol. Appl. Pharm., 160, 33-42 https://doi.org/10.1006/taap.1999.8741
  10. Casillas, E., M.S. Myers, L.D. Rhodes and B.B. McCain. 1985. Serum chemistry of diseased English sole, Paraphys vetulus Girard, from polluted areas of Puget Sound, Washington. J. Fish Dis., 8, 437-449 https://doi.org/10.1111/j.1365-2761.1985.tb01277.x
  11. Duncan, D.B. 1955. Multiple-range and multiple F tests. Biometrics, 11, 1-42 https://doi.org/10.2307/3001478
  12. Extonet. 1993. http://extoxnet.orst.edu/pips/parathio.htm
  13. Gallo, M.A., and N.J. Lawryk, 1991. Organic phosphorus pesticides. In: Handbook of Pesticide Toxicology, W.J. Hayes, Jr. and E.R. Laws, Jr., eds. Academic Press, San Diego, 2, 917-1123
  14. Gluth, G and W. Hanke. 1984. The comparison of physiological changes in carp, Cyprinus carpio, induced by several pollutants at sublethal concentra tions. II. The dependency on the temperature. Compo Biochem. Physiol., 79C, 39-45
  15. Goel K. A., K. Sandhya and V.P. Agarwal. 1984. Alachlor toxicity to a freshwater fish Clarias batrachus. Curro Sci., 53, 1051-1052
  16. Guobaitis, R.J., T.J. Ellingham and M.B. Maddock. 1986. The effects of pretreatment with cytochrome P450 inducers and preincubation with a cytochrome P450 effector on the mutagenicity of genotoxic carcinogens mediated by hepatic and renal S9 from two species of maLne fish. Mut. Res., 164, 59-70 https://doi.org/10.1016/0165-1161(86)90042-7
  17. Gupta A.K and S.S. Dhillon. 1983. The effects of a few xenobiotics on certain phosphates in the plasma of Clarias batrachus and Cirrhina rnrigala. Toxicol. Lett., 15, 181-186 https://doi.org/10.1016/0378-4274(83)90213-8
  18. Haux, C. and A. Larsson. 1984. Longterm sublethal physiological effects on rainbow trout, Salrno gairdneri, during exposure to cadmium and after subsequent recovery. Aquat. Toxicol., 5, 129-142 https://doi.org/10.1016/0166-445X(84)90004-3
  19. Jayantha Rao K., B. Azhar and K. Ramamurthy. 1984. Effect of a systemic pesticide phosphamidon on some aspects of freshwater fish Tilapia rnossarnbica. Indian J. Environ. Health, 26, 60-64
  20. Kim, L.S. and J.Y. Park. 2002. Freshwater Fishes of Korea. Kyo-Hak Pub. Co., Ltd., 235-237
  21. Lal, B., A. Singh, A. Kumari and N. Sinha. 1986. Biochemical and haematological changes following malathion treatment in the freshwater catfish Heterapneustes fossilis (Bloch). Environ. Pollut. Ser. A Ecol. Biol., 42, 151-156 https://doi.org/10.1016/0143-1471(86)90004-8
  22. Lee, K.M. 2000. A Survey on the Pesticide Use and Its Health Effects among the Farmers. PhD. Thesis, Seoul National University, 17
  23. Leroy C.F. 1993. Effects of chemical contaminants on blood chemistry of teleost fish: a bibliograhy and synopsis of selected effects. Environ. Toxicol. Chem., 12, 337-375 https://doi.org/10.1897/1552-8618(1993)12[337:EOCCOB]2.0.CO;2
  24. Li, Y.Q. 1999. Toxic Effects of Organophosphorus Pesticides on Marine Animals. Mariculture. Protection and Improvement of the Ecological Environments. Shandong Publishing House, Jinan., pp. 26-60
  25. MTPWWM (Ministry of Transport, Public Works and Water Management). 1998. Framework for Water. Fourth national policy document on water management. Government Decision
  26. Nataraj an, G.M. 1984. Effect of sublethal concentration of metasystox on selected oxidative enzymes, tissue respiration, and hematology of the freshwater airbreathing fish, Channa striatus (Bleeker). Pestic. Biochem. Physiol., 21, 194-198 https://doi.org/10.1016/0048-3575(84)90054-3
  27. Oruc, E.$\ddot{O}$. and N. $\ddot{U}ner$., 1998. Effects of azinphosmethyl on some biochemical parameters in blood, muscle, and liver Tissues of Cyprinus carpio (L.). Pestic. Biochem. Physiol., 62, 65-71 https://doi.org/10.1006/pest.1998.2367
  28. Oruc, E.$\ddot{O}$. and N. $\ddot{U}ner$. 1999. Effects of 2,4-Diamin on some parameters of protein and carbohydrate metabolisms in the serum, muscle and liver of Cyprinus carpio. Environ. Pollut., 105, 267-272 https://doi.org/10.1016/S0269-7491(98)00206-1
  29. Ram, R.N. and S.K. Singh. 1988. Carbofuran induced histopathological and biochemical changes in liver of the teleost fish, Channa punctatus (Bloch) Ecotoxicol. Environ.l Saf. 16, 194-201 https://doi.org/10.1016/0147-6513(88)90050-4
  30. Rojas, M., E. Bustos Obregon, F. Martinez Garcia, H. Contreras and J. Regadera. 1998. The effect of parathion on mouse testicular and epididymal development cultured in chicken allantochorion. Adv. Exp. Med. Bio., 444, 201-206 https://doi.org/10.1007/978-1-4899-0089-0_23
  31. Sadhu, K.A., DX. Chowdhury and P.K. Mukhopadhyay. 1985. Relationship between serum enzymes, histological features and enzymes in hepatopancreas after sublethal exposure to malathion and phosphamidon in the murrel Channa striatus. lnt. J. Environ. Stud., 24, 35-41 https://doi.org/10.1080/00207238508710174
  32. Sancho, E., M.D. Ferrando and E. Andreu. 1998. In vivo inhibition of AChE activity in the European eel Anguilla anguilla exposed to technical grade fenitrothion. Comp. Biochem. PhysioI., C 120, 389-395
  33. Singh, H. and T.P. Singh. 1980. Effect of two pesticides on total lipid and cholesterol content of ovary, liver and blood serum during different phases of the annual reproductive cycle in the freshwater teleost Heteropneustes fossilis (Bloch). Environ. Pollut. Ser. A Ecol. Biol., 23, 9-17 https://doi.org/10.1016/0143-1471(80)90092-6
  34. Van den Beukel, I., R.G. van Kleef, M. Oortgigiesen. 1998. Differential effects of physostigmine and organophosphates on nicotllllc receptors in neuronal cells of different species. Neurotoxicology, 19, 777-787
  35. Verma, S.R., S. Rani, P.I. Tonk and R.C. Dalela. 1983. Pesticide induced dysfunction in carbohydrate metabolism in three freshwater fishes. Environ. Res. 32, 127-133 https://doi.org/10.1016/0013-9351(83)90199-8
  36. Veronesi, B. and M. Ehrich. 1993. Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides. Toxicol. Appl. Pharm. 120, 240-246 https://doi.org/10.1006/taap.1993.1108