Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
권호 표지

Incidence Density of Antibody against Hepatitis C Virus in Seoul and Gyeonggi Area; A Retrospective Cohort Study - Based on Medical Screening Data from a General Hospital -

서울 경기지역 성인의 C형 간염 바이러스 항체 양성자 평균발생률; 후향적 코호트 연구 - 일개 병원의 종합검진 자료를 중심으로 -

  • Ryu, Seung-Ho (Department of Occupational Medicine, Health Screenig Center, Kangbuk Samsung Hospital & Sungkyunkwan University, School of Medicine) ;
  • Kim, Dong-Il (Department of Occupational Medicine, Kangbuk Samsung Hospital & Sungkyunkwan University, School of Medicine) ;
  • Suh, Byung-Seong (Department of Occupational Medicine, Kangbuk Samsung Hospital & Sungkyunkwan University, School of Medicine) ;
  • Kim, Woon-Sool (Department of Occupational Medicine, Health Screenig Center, Kangbuk Samsung Hospital & Sungkyunkwan University, School of Medicine) ;
  • Chang, Yoo-Soo (Health Screenig Center, Kangbuk Samsung Hospital & Sungkyunkwan University, School of Medicine) ;
  • Beck, Sung-Ho (Department of Family Medicine and Health Promotion, Seoul Paik Hospital, Inje University) ;
  • Lee, Soo-Jin (Department of Occupational and Environmental Medicine, Hanyang University College of Medicine) ;
  • Kim, Yong-Kyu (Department of Occupational and Environmental Medicine, Hanyang University College of Medicine) ;
  • Song, Jae-Chul (Department of Occupational and Environmental Medicine, Hanyang University College of Medicine)
  • 류승호 (성균관의대 강북삼성병원 산업의학과, 종합건진센터) ;
  • 김동일 (성균관의대 강북삼성병원 산업의학과) ;
  • 서병성 (성균관의대 강북삼성병원 산업의학과) ;
  • 김원술 (성균관의대 강북삼성병원 산업의학과, 종합건진센터) ;
  • 장유수 (성균관의대 강북삼성병원 종합건진센터) ;
  • 백승호 (인제의대 서울백병원 가정의학과) ;
  • 이수진 (한양대학병원 산업의학과) ;
  • 김용규 (한양대학병원 산업의학과) ;
  • 송재철 (한양대학병원 산업의학과)
  • Published : 2004.12.01
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Abstract

Objectives : This study was performed to determine the incidence density and the prevalence of sero-positive hepatitis C from 1999 to 2002 among adults aged 20 and over residing in Seoul and the Gyeonggi province. Method : The data for period was obtained from 114,635 adults, residing in Seoul or the Gyeonggi province, who had undertaken comprehensive health screening tests from Jan 1999 to Dec 2002 in a University hospital in Seoul. Among them, subjects with sero-negative status against hepatitis C were selected (21,408 in 1999, 28,830 in 2000) and then followed up until Dec 2002 to determine the incidence of hepatitis C during this period. The serum was tested with the immunoradiometric assay (IRMA) which uses third generation HCV antibody. Age adjusted rates were estimated by direct standardization using a reference population of 2000 aged from 20 to 80 years. Results : The prevalence of anti-HCV from 1999 to 2002 was 2.1 per 1000 persons(95% CI $1.8{\sim}2.4$). Male showed 1.7 per 1000 persons (95% CI $1.4{\sim}2.1$), while female showed 2.7 per 1000 persons(95% CI $2.2{\sim}3.2$). Age?sex adjusted rate showed 2.8 per 1000 persons (95% CI $2.64{\sim}2.96$), which is lower than the results of some previous study. The prevalence showed a significantly increasing pattern with age both in males and females (p<0.05). The incidence density of anti-HCV among the population aged 20 and over was 1.1 per 104 person-years at risk (95% CI $0.6{\sim}2.4$); 1.2 (95% CI $0.6{\sim}2.7$) for males and 0.8 (95% CI $0.6{\sim}4.2$) for females. Age adjusted incidence density was 2.91 per 104 person-years at risk (95% CI $2.43{\sim}3.38$) for those aged 20 and over. It showed an increasing pattern with age (p<0.05), especially for those age over 50 years. Conclusion : The study subjects for this study were supposedly healthier than the general population so the prevalence and incidence for the general population are thought to be higher than the results of the present study.

Keywords

References

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