Solvent Effect on Preservation and Inversion of the Chirality in the Processes of Nucleophilic Substitution Reaction of Organic Compound bearing Optical Activity Resolution

광학활성 분리능을 갖는 유기화합물의 친핵성치환반응에서 키랄성의 유지 및 반전에 미치는 용매효과

A systematic investigation for the reactivity and solvent effect was studied on the reaction of optical resolving agents with the optically active assistant compounds. The reaction rate constants of the nucleophillic substitution reactions were determined by means of conductometric method The linear solvent energy relationship based on the solvent parameters and the thermodynamic parameters was discussed on the reactions of various physiological active compounds and optical resolving agents The reaction mechanism was discussed from the kinetic results compared with the optical purity.