Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
권호 표지

Preventive Effects of Cricket Extracts, Gryllus bimaculatus, against Toxicity Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Rats

Rat에서 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin 유도 독성에 대한 귀뚜라미 추출물의 보호효과

  • Lee, Nam Jin (College of Veterinary Medicine, Chungbuk National University) ;
  • Park, Jong Bae (Department of Biology and Institute of Traditional Medicine & Bioscience, Daejeon University) ;
  • Kim, Dong Kyu (College of Veterinary Medicine, Chungbuk National University) ;
  • Yun, Chi-Young (Department of Biology and Institute of Traditional Medicine & Bioscience, Daejeon University) ;
  • Bae, Hyung Joon (Department of Clinical Laboratory Science, Seoul Health College) ;
  • Cho, Jung-Hee (College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Jong-Koo (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Yun Bae (College of Veterinary Medicine, Chungbuk National University) ;
  • Hwang, Seock Yeon (Department of Laboratory Medicine, Chungbuk National University)
  • 이남진 (충북대학교 수의과대학) ;
  • 박종배 (대전대학교 생물학과 및 동서생명과학연구원) ;
  • 김동규 (충북대학교 수의과대학) ;
  • 윤치영 (대전대학교 생물학과 및 동서생명과학연구원) ;
  • 배형준 (서울보건대학 임상병리과) ;
  • 조정희 (충북대학교 수의과대학) ;
  • 강종구 (충북대학교 수의과대학) ;
  • 김윤배 (충북대학교 수의과대학) ;
  • 황석연 (충북대학교병원 진단검사의학과)
  • Published : 2004.12.31
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Abstract

This study was carried out to investigate preventive effects of extracts of cricket, Gryllus bimaculatus, against the 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)-induced toxicity in 7-week-old Sprague-Dawley male rats. Thirty five male rats were divided into 5 groups: one normal control group treated with vehicle and saline (G1); one TCDD-treated group by single intraperitoneal injection (G2); three preventive groups (G3, G4, and G5). The last three groups, G3, G4, and G5, were fed on cricket extracts (50, 100, and 200 mg/kg, respectively) for 2 weeks before TCDD treatment. Various harmful effects were shown by TCDD treatment. The body weights of rats were lost by TCDD. In addition, severe hypertrophy and color change, and the weights gaining were found in the livers of TCDD-treated rats. It was observed that the cytoplasmic vacuolizations and inflammatory cell infiltration around portal triad in the liver. TCDD also elevated the serum activity levels of alanine transaminase(ALT) and aspartate transaminase(AST). However, those losses were compensated by cricket extracts treatment at the level of 200 mg/kg. These findings indicate that cricket extracts may have protective effects against TCDD-induced toxicities in rats.

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