Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Effects of mixture of fibrin-fibronectin sealant system and calcuim carbonate in periodontal intrabony defects

calcium carbonate와 fibrin-fibronectin sealant system 혼합이식이 치주골내낭 치유에 미치는 영향

  • Chang, Soo-Jin (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • Han, Dong-Kwan (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • Yun, Jeong-Ho (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • Jung, Ui-Won (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • Kim, Chang-Sung (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • Choi, Seong-Ho (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • Cho, Kyoo-Sung (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University) ;
  • Chai, Jung-Kiu (Department of Periodontology, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University)
  • 장수진 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단) ;
  • 한동관 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단) ;
  • 윤정호 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단) ;
  • 정의원 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단) ;
  • 김창성 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단) ;
  • 조규성 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단) ;
  • 김종관 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단) ;
  • 채중규 (연세대학교 치과대학 치주과학교실, 구강과학연구소, BK21 의과학 사업단)
  • Published : 2004.09.30
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Abstract

Calcium carbonate(CC) is biocompatible and gradually absorb to be replaced by bone when implanted into bone tissue. Fibrin-fibronectin sealant system (FFSS) is a product of human-derived plasma. The effect is hemostasis, tissue fixation and adhesion, We expect synergic effects of this two materials in periodontal regeneration. When FFSS was grafted with bone graft in intrabony defects, could be eliminated exofolication of bone graft materials. This study evaluated above materials for periodontal regeneration of 6mm intrabony defects in 36 patients. lap surgery was carried in 14 defects of control group. experimental group 1 was 11 defects grafted with calcium carbonate, experimental group 2 was 11 defects which were grafted with calcium carbonate with FFSS. The clinical parameters evaluated included changes in attachment level, probing depth, gingival recession at 6 months. Postsurgery probing depth reduction was 3.1 ${\pm}$ 0.9mm in control, 3.8 ${\pm}$ 1.6mm in experimental group 1, 4.1 ${\pm}$ 1.1mm in experimental group 2. The result clinically and statistically improved compared to baseline(P<0.01), but the difference found among the groups were not statistically significant. Postsurgery clinical attachment level was 1.6 ${\pm}$ 1.2mm in control, 3.5 ${\pm}$ 2.0mm in experimental group 1, 3.3 ${\pm}$ 1.2mm in experimental group 2. All of the control and experimental groups resulted in a statistically significant reduction from baseline(P<0.01). The reduction of the experimental groups were statistically significant from control(P<0.05). But the change between experimental group 1 and experimental group 2 was not statistically significant. We conclude that mixture of CC and FFSS is effective to periodontal regeneration in intrabony defect.

Keywords

References

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