Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on the Effects of Tuber Pinelliae on the Blood Vessels

반하가 혈관에 미치는 영향

  • Kim Ho Geun (Department of Pharmaclolgy, College of Oriental Medicine, Wonkwang University) ;
  • Baek Eun Jung (Department of Pharmaclolgy, College of Oriental Medicine, Wonkwang University) ;
  • Han Sang Gun (Department of Pharmaclolgy, College of Oriental Medicine, Wonkwang University) ;
  • Choi Byung Wha (Department of Pharmaclolgy, College of Oriental Medicine, Wonkwang University) ;
  • Han Jong Hyun (Department of Pharmaclolgy, College of Oriental Medicine, Wonkwang University)
  • 김호근 (원광대학교 한의과대학 약리학교실) ;
  • 백은정 (원광대학교 한의과대학 약리학교실) ;
  • 한상건 (원광대학교 한의과대학 약리학교실) ;
  • 최병화 (원광대학교 한의과대학 약리학교실) ;
  • 한종현 (원광대학교 한의과대학 약리학교실)
  • Published : 2004.08.01
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Abstract

The purpose of the present study is to measure the effect of Tuber Pinelliae on EP(epinephrine) induced contraction of isolated rat thoracic aorta. Contractile force was measured with force displacement transducer under 1.5g loading tension. The mean percent increasing of rCBF was 11.4% (p<0.05) after 10㎎/㎏ Tuber Pinelliae. Contractions evoked by EP (ED50) and KCI 65.4mM were decreased significantly by Tuber Pinelliae. L-NNA, ODQ and atropine significantly altered the effect of Tuber Pinelliae, but propranolol and indomethacin did not change the relaxation of Tuber Pinelliae. These results indicate that Tuber Pinelliae can relax EP and KCI induced contraction of isolated rat thoracic aorta and that this decreasing contraction related to epithelium, nitric oxide, and parasympathetics.

Keywords

References

  1. 원색 임상본초학 신민교
  2. 中藥大辭典 김창민(외)
  3. 圖解鄕約(生藥)大辭典(食物篇) 정보섭;신민교
  4. 韓藥의 藥理 김형균(외)
  5. 한방약리학 한국생약교수협의회(편)
  6. 본초학 전국한의과대학 본초학교수(편)
  7. Chem. Pharm. Bull. v.26 Isolation of l-Ephedrine from Pinelliae Tuber H. Oshio;M. Tsukui;T. Matsuoka
  8. Tohoku J. Exp. Med. v.17 Pinellia ternata Breit.의 球根으로부터 얻은 알칼로이드의 作用 鈴木達
  9. 화한약물학 高木敬次朗
  10. 중약약리학 王筠默
  11. Tohoku. J. Exp. Med. v.17 半夏球根(Pinellia ternata BREIT)의 鎭吐작용 鈴木達
  12. 崎阜醫科大學紀要 v.6 半夏(Pinella)의 鎭吐作用에 대해서 高部登
  13. Nippon Yakurigaku Zasshi v.72 no.3 Effectiveness of several antiemetics in vomiting induced by orally administrated copper sulfate in cats and dogs Kayashima N;Hayama T.
  14. 崎阜醫科大學紀要 v.7 半夏(Pinella)의 鎭咽痛作用에 대해서 高部登
  15. Am J Chin Med. v.28 no.2 Influence of spleen meridian herbs on the harmonic spectrum of the arterial pulse Wang WK;Bau JG;Hsu TL;Wang YY.
  16. Planta Med. v.59 no.2 Effects of kampo (Japanese herbal) medicine sho-saiko-to on DNA-synthesizing enzyme activity in 1,2-dimethylhydrazine-induced colonic carcinomas in rats. Sakamoto S;Mori T;Sawaki K;Kawachi Y;Kuwa K;Kudo H;Suzuki S;Sugiura Y; Kasahara N;Nagasawa H.
  17. Am J Reprod Immunol. v.39 no.4 The herbal medicine unkei-to stimulates cytokine-induced neutrophil chemoattractant production in the pituitary folliculo-stellate-like cell line (TtT/GF) Koike K;Zhang ZX;Sakamoto Y;Jikihara H;Masuhara K;Murakami K;Miyake A;Inoue M.
  18. Pathol Int. v.47 no.7 Suppressive effects of sairei-to on monoclonal antibody 1-22-3-induced glomerulonephritis: analysis of effective components Li P;Kawachi H;Morioka T;Orikasa M;Oite T;Shi ZS;Shimizu F.
  19. Biol Pharm Bull. v.19 no.7 A polysaccharide fraction of Zizyphi fructus in augmenting natural killer activity by oral administration Yamaoka Y;Kawakita T;Kaneko M;Nomoto K.
  20. Cesk Farm. v.42 no.2 Herbal drugs in Kampo preparations Hubik J;Spilkova J.
  21. Int J Immunopharmacol. v.15 no.2 Role of B-lymphocytes in the immunopharmacological effects of a traditional Chinese medicine, xiao-chai-hu-tang (shosaiko-to) Matsuura K;Kawakita T;Nakai S;Saito Y;Suzuki A;Nomoto K.
  22. Planta Med. v.58 no.3 Mitogenic activities in the protein fractions of crude drugs Tachibana Y;Kawanishi K.
  23. Nippon Yakurigaku Zasshi v.96 no.5 Effects of Shosaiko-to-go-keishikashakuyaku-to (TJ-960) on the valproic acid induced anomalies of rat fetuses Minematsu S;Taki M;Watanabe M;Takahashi M;Wakui Y;Ishihara K;Takeda S; Fujii Y.
  24. Zhong Xi Yi Jie He Za Zhi. v.10 no.11 Quantitative Chinese pharmaceutical study on children pneumonia treated by Pu fu-zhou Dong GY
  25. J. Moll cell cardiol. v.31 The alternative: EDHF F'el'etou, M.;Vanhoutte, P. M.
  26. Am. J. Physiol. Heart circ. Physiol. v.278 In eNOS knockout mice skeletal muscle arteriolar dilation to acetylchorine is mediated by EDHF Huang, A.;Sun, D.;Smith, C. J.;Counetta, J. A.;Shesely, E. G.;Koller, A.;Kaley, G.
  27. Am. J. Physiol. v.273 Components of acetylcholine-induced dilation in isolated rat arterioles Bakker, E. N. T. P.;Sipkema, P.
  28. FASEB J. v.3 no.1 Endothelium-derived nitric oxide: action and properties Ignarro, L. J.
  29. Eur. J. Pharm. v.274 Endothelium-dependent relaxation resistant to NG-nitro-L-arginine in rat aorta Hadake, K.;Wakabayashi, I.;Hishda, S.
  30. Cicr Res. v.83 A major role for prostacyclin in nitric oxide-induced occular vasorelaxation in the piglet Hardy, P.;Abran, D.;Hou, X.;Lahaie, I.;Peri, K. G.;Asselin, P.;Varma, D. R.;Chemtob, S.
  31. Physiol. Pflugers Arch, ges.
  32. Statistical Methods Snedecor, G. H.;W. G. Cochran
  33. 崎阜醫科大學紀要 v.7 半夏(Pinella)의 解毒作用에 대해서 高部登