Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Induction of FSTL1 Gene in Rat Myometrium by Exogenous Estrogen

  • Kim Yoon-Sik (Department of Cytogenetics & In Vitro Fertilization Division, Kwangju Christian Hospital,) ;
  • Kim Yeon (Department of Laboratory Medicine, Kwangju Christian Hospital) ;
  • Bae Hyung-Joon (Department of Clinical Laboratory Science Seoul Health College)
  • Published : 2004.12.01
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Abstract

The aim of this study was carried to the induction of follistatin-like 1 (FSTL1) in rat myometrium tissue by exogenous estrogen. PCR was performed by using estrogen treatment after ovariectomy of myometrium mRNA and only ovariectomy of myometrium mRNA and on ovariectomy of myometrium mRNA in rat normal uterus tissue. The PCR products were visualized on agarose gel (1.2％) electrophoresis. FSTL1 mRNA expression level was significantly higher (**P<0.001 or *P<0.05) in estrogen treatment after ovariectomy than in only ovariectomy, and was significantly higher (**P<0.001) in no ovariectomy than in estrogen with treatment after ovariectomy. In conclusion, Although the mechanisms of FSTL1 gene were uncertain, It also might be inducted by exogenous estrogen. And also it is thought to be related to the estorgen mechanism.

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