Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Effects of Subacute Oral Administration of Mancozeb on the Immunopathological Parameters and Splenocytes Proliferation in Mice

Mancozeb의 아급성 노출이 마우스의 면역병리학적 인자 및 비장세포 증식능에 미치는 영향

  • 표명윤 (숙명여자대학교 약학대학) ;
  • 정애희 (서울특별시보건환경연구원)
  • Published : 2004.12.01
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Abstract

Mancozeb, a polymeric complex of zinc and manganese salts of ethylene bisthiocarbamate (EBDC), is used widely in agriculture as fungicides, insecticides, and herbicides. Mancozeb can be occupationally and environmentally exposed to human and has been reported to induce estrogenic activity, therein it is considered as an endocrine disrupter. After female ICR mice were treated Mancozeb orally at the doses of 250, 1,000 and 1,500 mg/kg/day for consecutive 30 day, we investigated the effects of Mancozeb on the immunopathological parameters (body-, thymus-, spleen-, liver- and kidny-weight, splenic cellularity, hematological parameters) and mitogen (Con A, LPS)-induced splenocyte proliferation (SP). Liver- and kidney- weight were increased, but body- and thymus-weight, number of splenocytes and WBC were decreased, when compared with control group. When splenocytes isolated from the mice exposed to Mancozeb for 30 days were cultured in presence of mitogens, the SP against Con A was significantly and dose-dependently decreased and the SP against LPS was also slightly decreased. Our present results indicate that subacute exposure of Mancozeb to mice might show immunotoxic effect.

Keywords

References

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