References
- EvansMJ, Kaufman M. Establishment in culture of pluripotential stemcells frommouse embryos. Nature 1981; 292: 151-6
- Thomson JA, Itskovitz-Eldor J, Shapiro SS,Waknitz MA, Swiergiel Jl, et al. Embyronic stem cell lines derivedfrom humanblastocysts. Science1998; 282: 1145-7 https://doi.org/10.1126/science.282.5391.1145
- Shamblott MJ, Axelman J, Wang S, Bugg EM, Li-ttlefield JW, Donovan PJ, et al. Human embryonic germ cell derivativesexpress a broad range of deve-lopmentally distinct markers and proliferate exten-sively in vitro. Proc Natl Acad Sci USA 2001; 98: 113-8 https://doi.org/10.1073/pnas.021537998
- Reubinoff BE, Pera MF,Fong CY,Trounson A, Bo-ngso A. Embryonic stem cell lines from human bla-stocysts: Somatic differentiationin vitro. Nat Biote-chnol 2000; 18: 399-404 https://doi.org/10.1038/74447
- Park JH,Kim SJ, Oh EJ,Moon SY,Roh SI, Kim CG, et al. Establishment and maintenance of human em-bryonic stem cells on STO, a permanently growing cell line. BioI Reprod 2003; 69: 2007-14 https://doi.org/10.1095/biolreprod.103.017467
- McDonaldJW,Liu XZ, Qu Y, Liu S, Mickey SK, Tu-retsky D, Gottlieb DI, et al.Transplantedembryonic stem cells survive, differentiate and promote reco-very in injured rat spinal cord. Nat Med 1999; 5: 1410-2 https://doi.org/10.1038/70986
- Brustle O, Jones KN, Learish RD, Karram K, Cho-udhary K, Wiestler OD, et al. Embryonic stem cell-derived glial precursors:A source of myelinating tr-ansplants. Science 1999; 285: 754-6 https://doi.org/10.1126/science.285.5428.754
- Soria B, Roche E, Bema 0, Leon-QuintoT, Reig JA, Martin F. Insulin-secreting cells derived from embr-yonic stem cells normalize glycaemia in streptozo-tocin-induced diabeticmice. Diabetes 2000; 49: 15762
- Deacon T, Dinsmore J, CostantiniLC, Ratliff J, Isa-cson O. Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after tra-nsplantation. Exp Neurol 1998; 149:28-41 https://doi.org/10.1006/exnr.1997.6674
- Lumelsky N, Blondel O, Laeng P,VelascoI, Ravin R, McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similarto pancreaticislets. Science 2001; 292: 1389-94 https://doi.org/10.1126/science.1058866
- Assady S, Maor 0, Arnit M, Itskovitz-Eldor J, Sko-recki K, Tzukerman M. Insulin production by human embryonic stem cells. Diabetes 2001; 50: 1691-7 https://doi.org/10.2337/diabetes.50.8.1691
- Hori Y,RulifsonIC, TsaiBC, Heit JJ, CahoyJD,Kim SK. Growth inhibitors promote differentiationof in-sulin-producing tissue from embryonic stem cells. Proc NatlAcad Sci USA 2002; 99: 16105-10 https://doi.org/10.1073/pnas.252618999
- Abraham EJ, Leech CA, Lin JC, Zulewski H, Habe-ner JF. Insulinotropic hormone glucagon-like pepti-de-l differentiation of human pancreatic islet-derived progenitorcells into insulin-producing cells. Endocrinology 2002; 143: 3152-61 https://doi.org/10.1210/en.143.8.3152
- Blyszczuk P, Czyz J, Kania O, Wagner M, Roll U, St-Onge L, Wobus A. Expression of Pax4 in embryonic stem cells promotes differentiation of nesti-npositive progenitorand insulin-producing cells. Proc NatlAcad Sci USA 2003;100: 998-1003 https://doi.org/10.1073/pnas.0237371100
- Houard N, Rousseau Go, Lemaigre FP. HNF-6-independentdifferentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia 2003; 46: 378-85 https://doi.org/10.1007/s00125-003-1041-8
- Moritoh Y, Yamato E, Tasui Y, Miyazaki S, Miya-zaki J. Analysis of insulin-producingcells during in vitro differentiation from feeder-free embryonicstem cells. Diabetes 2003; 52: 1163-8 https://doi.org/10.2337/diabetes.52.5.1163
- Kim D, Gu Y, Ishii M, Fujimiya M, Qi M, Nakamura N, et al. In vivo functioning and transplantable mature pancreatic islet-like cell clusters differenti-ated from embryonic stem cell. Pancreas 2003; 27: 34-41 https://doi.org/10.1097/00006676-200308000-00021
- Sipione S, Eshpeter A, Lyon Jo, Korbutt GS, Blea-ckley RC. Insulin expressing cellsfrom differentiated embryonic stem cells arenot beta cells. Diabetologia 2004;47: 499-508 https://doi.org/10.1007/s00125-004-1349-z
- Leon-QuintoT, JonesJ, SkoudyA, BurcinM, Soria B. In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia 2004;47: 1442-51
- Segev H, Fishman B, ZiskindA, Shulman M, Itsko-vitz-Eldor J. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 2004; 22: 265-74 https://doi.org/10.1634/stemcells.22-3-265