한국자원식물학회지 (Korean Journal of Plant Resources)

  • 제17권3호
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  • Pages.323-330
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  • 2004
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  • 1226-3591(pISSN)
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  • 2287-8203(eISSN)
한국자원식물학회 (The Plant Resources Society of Korea)
권호 표지

금앵자(金櫻子) 추출물이 과산화지질을 급여한 흰쥐의 혈청지질구성과 할산화능에 미치는 영향

Effects of Guemengja (Rosae Laevigatae Michx.) Extracts on Serum Lipid Composition and Antioxidative Capacity in Rats Fed High Oxidized Fat

  • 발행 : 2004.10.01
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초록

금앵자 추출물이 과산화지 질을 급여한 횐 쥐의 혈장 및 간장지질구성과 항산화능에 미치는 영향을 검토했다 혈장 총 콜레스테롤 량은 과산화지질 첨가군 모두가 정상군보다 증가하였으나, 금앵자 추출물 첨가에 의해 하락하였다. 혈장HDL-cholesterol량은 금앵자 첨가군이 대조군 보다 높은 경향을 나타내었다. 혈장 중성지질량은 정상군과 금앵자 첨가군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다. 간장의 총 콜레스테롤 량은 전 처리군에서 유의한 차이를 나타내지 않았으며, 중성지질 량은 정상군과 금앵자 첨가군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다 혈장내 TBARS량은 정상군과 금앵자군은 유의한 차이를 나타내지 않았으며, 대조군 보다 낮은 수치를 보였다. 간장내 TBARS량은 과산화지질 첨가에 의해 증가하였으나, 금앵자 첨가에 의해 하락했다. 혈장 GOT 및 GPT의 활성치는 관산화지질 첨가군에서 증가하였으나, 금앵자처리에 의해 하락했다(P＆lt;0.05). 간장 GSH-Px, SOD 및 CAT활성치는 금앵자처리에 의해 증가하는 경향을 보였다.

Effects of Guemengja (Rosae Laevigatae Michx.) Extracts on serum and liver lipid composition and antioxidative capacity were investigated in rat fed high oxidized fat. Twenty eight male Sprague-Dawley rats weighing 159.35$\pm$2.17g were blocked into four groups according to body weight and raised seven weeks with basal diet (normal group, I), basal diet and 10% oxidized fat (control group, II), basal diet, 10% oxidized fat and 100mg/kgg Guemengja Extracts (100mg/kg Guemengja Extracts group, III) and basal diet, 10% oxidized fat and 200mg/kg Guemengja Extracts (200mg/kg Guemengja Extracts group, IV). The level of plasma total cholesterol and triglyceride showed a tendency to decrease, whereas the plasma HDL-cholesterol concentration revealed a tendency to increase in guemengja extracts groups. The level of liver total cholesterol showed no significantly different in all treatment groups, however the level of liver triglyceride showed a tendance to decrease in guemengja extracts groups. Thiobarbituric acid(TBARS) values in plasma and liver showed a tendence to decrease in guemengja extracts groups. The guemengja extracts samples have also decreased the plasma GOT and GPT activities, whereas they have increased the liver glutathione peroxidase, superoxide dismutase and catalase activity.

키워드

참고문헌

  1. Ahrens EH, Insull WJ, Blomstrand R, Hirsh J, Tsaltas TT, Peterson MI. 1957. The influence of dietary fat on serum lipids levels in man. Lancet 1: 943-954
  2. Bidlack WR, Tappel AL. 1973. Damage to microsomal membrane by lipid peroxidation. Lipids 8: 177-178 https://doi.org/10.1007/BF02544631
  3. Buege JA, Aust SD. 1978. Microsomal lipid peroxidation. In: Fleischer S, Packer L eds Methods in enzymelogy(London, Academic press) 52: 302-309
  4. Chung YJ, Park HJ, Chang YK. 1994. Effect of dietary eicosapentaenoic acid on serum and liver lipids paterns of mail rat. Korean J Nutr 27:537-551
  5. Flohe L, Becker R. Brigelius R. Lengfelder E. Otting F. Convenient as says for superoxide dismutase. CRC Handbook of free radicals and antioxidants in Biomedicine ,287-293, 1992
  6. Hang A, Hostmark AT. 1987. Lipoprotein lipases, lipoprotein and tissue lipids in rats fed fish oil or coconut oil. J Nutr 117: 1011 - 1017
  7. Harris WS, Connor WE, McMurry MP. 1983. The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils. Metabolism 32: 179 - 184 https://doi.org/10.1016/0026-0495(83)90226-3
  8. Johnson LH, Hakan Borg LA. A spectrophtometric method for determination of catalase activity in small tissue samples. Analytical Biochemistry 1988, p.174, pp331-336
  9. Jung DW, Shibuya M, Ebizuka Y, Yoshimatsu K, Shimomura K, Chung KS. 1998. ELISA for the determination of saikosaponin a, an active component of Bupleuri radix. Chem Pharm Bull 46: 1140-1143 https://doi.org/10.1248/cpb.46.1140
  10. Kim SH, Jo MJ. 1972. A study of metabolic effect in high and low fat diet on albino rat. J Nutr 5: 169-183
  11. Kim WY, Park HS. 1981. The effect of dietary fat levels and protein source in early life on the cholesterol and lipid metabolism in adult rats. Korean J Nutr 14: 136-147
  12. Kang YH, Ha TY. Moon KD. 1996. Effects of pine needle extracts on serum and liver lipid contents in rats fed high fat diet. J Korean Soc Food Nutr 25: 367 - 373
  13. Langanier S, Yu BP. 1987. Anti-lipoperoxidation action of food restriction. Biochem Biophys Res Comm 145: 1185-1202 https://doi.org/10.1016/0006-291X(87)91562-2
  14. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358 https://doi.org/10.1016/0003-2697(79)90738-3
  15. Powell CJ, Connoly AK. 1988. The site specificity and sensitivity of the rats liver to butylated hydroxytoluene-induced damage. Toxicol Appl Pharmacoll5: 1127-1145
  16. Saito M. 1988. Interaction between lipid peroxide formation and nutritional status. J JPN Soc Nutr Food Sci 41: 343-349 https://doi.org/10.4327/jsnfs.41.343
  17. Sin MK, Han GJ. 1997. The effects of green tea on the serum lipid and liver tissue of cholesterol fed rats. Korean J Sci Technol29: 1255 - 1263
  18. Sanders TAB, Hochland MC. 1983. A comparison of the influence of on plasma lipids and platelet function of supplements of n-3 and polyunsaturated fatty acid. Brit J Nutr 50: 521-529 https://doi.org/10.1079/BJN19830123
  19. Vergroeson AT. 1997. Physiological effects of dietary linoleic acid. Nutr Rev 35: 1-9
  20. V.Levander OA, PDeLoach D, Morris C, Moser PB. 1983. Platelet glutathione peroxidase activity as an index of selenium status in rats. J Nutr 113: 55-63
  21. Younes M, Siegers CP. 1980. Lipid peroxidation as a consequence of glutathione depletion in rat and mouse liver. Res Comm Chem Path Pharm 27: 119- 129
  22. Yamaoka Y, Kawakita T, Kaneko M, Nomoto K. 1996. A polysaccharide fraction of Zizyphi fructus in augmenting natural killer activity by oral administration. Biol pharm Bull 19: 936-939 https://doi.org/10.1248/bpb.19.936
  23. Yoshikawa M, Murakami T, Hirano K, Inadzuki M, Ninomiya K, Matsuda H, Scorzonerosides AB, Novei C. 1997. Triterpene oligoglycosides with hepatoprotective effect from chines Bupleuri radix, the roots of Bupleurum scorzonerifolium willd. Telrahearon Letters 38: 7395-7398 https://doi.org/10.1016/S0040-4039(97)01733-4
  24. 김재길, 원색천연약물대사전, 남산당, p407,1984
  25. 남경약학원편, 약재학, 소화문화복무사, 홍통, p848, 1988
  26. 방춘인, 중국의약대성, 길림과학기술출판사, p534, 1994
  27. 신민교 감수(원광대21기편역), 본초구진, 194, 1999
  28. 신재용, 방약합편해설, 성보사, p583, 2000
  29. 연문주, 중국보초도록, 상무인서관(홍콩)유한공사, p65,1988
  30. 안정화, 중약학, 인민위생출판사, p891, 1991
  31. 허준, 대역동의보감, 법인문화사, p1976, 1999