Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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γ-Irradiation Induced Adhesion Molecules are Reduced by Vitamin C in Human Endothelial Cells

  • Son, Eun-Wha (Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Kim, Byung-Oh (College of Life Science and National Resources, Sangju University) ;
  • Pyo, Suh-Kneung (Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University)
  • Published : 2004.09.01
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Abstract

Inflammation is a frequent radiation-induced reaction following therapeutic irradiation. Treatment of human umbilical endothelial cells (HUVEC) with ${\gamma}$-irradiation (${\gamma}$IR) induces the expression of adhesion proteins such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. Since the upregulation of these proteins on endothelial cell Surface has been known to be associated with inflammation, interfering with the expression of adhesion molecules is an important therapeutic target. In the present study, we demonstrate that vitamin C inhibits ${\gamma}$IR induced expression of ICAM-1, VCAM-1, and E-selectin on HUVEC in a dose- and time dependent manner. Vitamin C a1so inhibited the production of Nitric oxide (NO) induced by ${\gamma}$IR. These data suggest that vitamin C has therapeutic potential for the treatment of various inflammatory disorder associated with an increase of endothelial leukocyte adhesion molecules.

Keywords

References

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