Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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The Anti-tumor Effect of Soonkiwhajungtang with Doxorubicin in Colon-26

순기화중탕(順氣和中湯)과 Doxorubicin의 병용이 Colon-26의 항암효과에 미치는 영향

  • Shin Min-Kyu (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Bong-Suk (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Oh Jung-Han (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Lim Hee-Yong (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Dong-Woo (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Choi Bin-Hye (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Sang-Chan (Department of Formulae Pharmacology, College of Oriental Medicine, Daegu Haany University) ;
  • Byun Joon-Seok (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
  • 신민규 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김봉석 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 오중한 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 임희용 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김동우 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 최빈혜 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김상찬 (대구한의대학교 한의과대학 방제학교실) ;
  • 변준석 (대구한의대학교 한의과대학 비계내과학교실)
  • Published : 2004.12.30
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Abstract

In order to evaluate the anti-tumor and synergic effect of Soonkiwhajungtang with doxorubicin, the inhibitory concentration(IC), $IC_{50}\;and\;IC_{90}$ of single use of doxorubicin and Soonkiwhajungtang with their concomitant treatment against Colon-26(Murine Rectum Carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst to Colon-26 cell lines. Soonkiwhajungtang has only mimic direct anti-tumor effect against to Colon-26 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that Soonkiwhajungtang extracts were reduced the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubidn and Soonkiwhajungtang extracts.

Keywords

References

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